Short-Chain Fatty Acids May Mediate the Effects of Maternal Malnutrition on Fetal Neurodevelopmental Outcomes via Regulation of HDAC4 Expression

Anne Waddle Introduction. In 2019, one-third of women of childbearing age were considered obese.1 Maternal malnutrition, including obesity, high-fat diet, and low-fiber diet, is associated with many neurodevelopmental disorders.2 Gut microbiota dysbiosis may play a mechanistic role in pathogenic pregnancy outcomes because of its role in the production of short-chain…
Development Gynecology

Inhibition of AT1R-B2R Aggregates Decreases Endothelial Calcium Signaling and Alleviates Preeclampsia

Chantal Kinsey Introduction. Preeclampsia is the leading cause of death of pregnant women and the most common pregnancy complication with gestational hypertension leading to end-organ dysfunction.1,2 The mechanism by which preeclampsia induces organ damage is similar to other hypertensive conditions mediated by the upregulation of renin-angiotensin system (RAS) and downregulation…
Gynecology Inflammation Reproduction

Restoring the Endometrial Microbiota to Overcome the Consequence of Infertility in Women with a History of Gynecologic Infection

Medha Narwankar Introduction. Pelvic inflammatory disease (PID) is a broad spectrum of reproductive tract infections that can cause inflammation and damage to fallopian tubes1,2. The endometrial microbiome creates a biofilm and dynamic interface that supports interaction between gametes, the embryo, and maternal tissue3. Statistics have shown that 2.5 million reproductive-aged…
Gynecology Microbiology

Minimally Invasive Preimplantation Genetic Testing for Aneuploidy in In vitro Fertilization

Natalie Miroballi Introduction. Infertile individuals often seek assisted reproductive technology (ART) to aid in conception, the most common of which is In vitro fertilization (IVF) therapy. The success rate of IVF is highly variable and depend on several clinical factors including the underlying causes of infertility and the woman’s age.…
Featured Abstracts Gynecology Reproduction

The Effects of Oxidative Stress on Endometriosis

Rachel Stading Introduction. Endometriosis is a chronic disease in which uterine tissue is implanted outside of the uterus1. This disease affects one in every 10 women2. The risk of endometriosis increases with increasing ovulatory cycles; therefore, women with less pregnancies or irregular menstrual cycles may be at higher risk of…
Gynecology