Category: Orthopedics

Innovations in Anterior Cruciate Ligament Reconstruction Methods: Internal Bracing

June 25, 2024 Nathan Harward
Nathan Harward Background: The anterior cruciate ligament (ACL) is the chief ligament within the knee joint, responsible for anterior and rotational stability1. Most ACL ruptures are sports-related, and ligament reconstruction is generally preferred over attempted repair, even if the tear is partial2. Approximately 200,000 ACL reconstructions (ACLR) are performed each…
Engineering Medicine Featured Abstracts Orthopedics

Addressing the Rotator Cuff Problem: Lessons from the Hamstring

June 24, 2024 Andrei Demkov
Andrei Demkov Background: Rotator cuff (RC) injuries are prevalent among orthopedic pathologies, significantly contributing to the surgical burden each year.1 These injuries exhibit a spectrum of severity from minor partial-thickness tears to extensive, retracted disruptions. Typically addressed through arthroscopic techniques, the recurrence of tears post-repair varies widely; smaller tears exhibit…
Engineering Medicine Featured Abstracts Orthopedics

The Positive Molecular Impacts of Exercise on Vascular Endothelial Growth Factor (VEGF) and Bone Angiogenesis in the Non-Pharmacological Treatment/Prevention of Osteoporosis

June 12, 2024 Leo Toussaint
Leo Toussaint Background: Osteoporosis (OP) is a skeletal disease involving the degeneration of bone structure, strength, and density resulting in an increased risk of fractures.1 OP affects over 12% of US adults over 50 and causes over 2 million fractures with a cost of up to $17 million annually.2 Risk…
Featured Abstracts Orthopedics

A Non-Invasive Approach Utilizes YAP in Platelet-Derived Exosomes to Treat Tendon Injury

June 10, 2024 Connor Roper
Connor Roper Background: Tendons are constantly responsible for a proportionally high force load and are crucial to normal function1. Tendon injuries, including tendinitis and tendinopathy, can severely impact life quality and reportedly affect over 100 million people globally2. Mechanical overuse and age-related degeneration of tenocytes most often contribute to tendon…
Featured Abstracts Orthopedics

Inhibition of MicroRNA-141 and MicroRNA-145 as Potential Therapeutic Targets for Promoting Bone Mesenchymal Stem Cell Proliferation in Steroid-Induced Avascular Necrosis of the Femoral Head (SANFH)

June 5, 2024 Jason Noor
Jason Noor Background: Avascular necrosis of the femoral head is an orthopedic disease that occurs when the femoral head receives an inadequate supply of blood. This eventually leads to deterioration or collapse of the femoral head.1 The most common non-traumatic risk factor of avascular necrosis of the femoral head is…
Featured Abstracts Orthopedics

Mesenchymal Stem Cells Used for Their Anti-Inflammatory and Immunomodulatory Properties to Treat and Hinder Progression of Osteoarthritis

May 30, 2024 Ryan James
Ryan James Background:  Osteoarthritis (OA) is the most common degenerative disease seen in the world, with women being up to 40% more likely to develop the disease.1 The activation of cytokines and matrix metalloproteinases (MMPs) are directly responsible for the destruction of cartilage tissue in OA.1,2 In OA, proinflammatory cytokines…
Featured Abstracts Inflammation Orthopedics Stem Cells

The Role of Curcumin as a Successful Modulator of Bone Mineralization and Resorption as a Treatment for Osteoporosis

May 30, 2024 Steven Maxwell
Caroline Harrison Background: Osteoporosis is the most common bone disease which is characterized by decreased bone density and abnormal microstructure, leading to an increased risk of fracture in affected individuals. Current treatments such as bisphosphonates are aimed at reducing future bone loss and slowing the progression of disease, leaving space…
Featured Abstracts Orthopedics