The Role of GBA Gene Deficiency in Parkinson’s Disease and Formation of Neurotoxic Lewy Bodies
Omar Shalaby Introduction: Mutations in the GBA gene are implicated in lysosomal storage diseases such as Gaucher disease but may also be important in the pathogenesis of Parkinson’s disease. Loss of function mutations in the GBA gene, which codes for glucocerebrosidase, have been shown to increase the risk of Parkinson’s…