Category: Cancer

Modulating the PI3K/AKT/mTOR Signaling Pathway with Novel Compounds to Improve Treatment of Castration-Resistant Prostate Cancer

June 22, 2023 Yusuf Zaidi
Yusuf Zaidi Background: Prostate cancer is a major global health concern.1 Castration-resistant prostate cancer (CRPC) is an advanced subtype that poses a significant challenge due to its resistance to therapeutic interventions, with effective treatment options for CRPC being limited. Various risk factors, including age, genetics, and lifestyle factors, have been…
Cancer

Overexpression of TGF-β1 by Glioblastoma Stem Cells Under the Influence of 2-Microglobulin Drives Mechanism of MGMT Mediated Temozolomide Resistance

June 22, 2023 Will Hlavinka
Will Hlavinka Background: Glioblastoma multiforme (GBM) is the most common primary intracranial malignancy in adults.1 GBM is a grade IV astrocytoma with a dismal mean survival time and two-year survival rate of 9-15 months and less than 10%, respectively.2,3,4,5 The current standard of care for GBM is surgical resection followed…
Cancer Featured Abstracts

Statistical Comparisons of Individual Glioblastoma Samples Can Reveal Molecular Subtypes with Clinical Phenotypes

June 22, 2023 Wengler James
Wengler James Background: Glioblastoma (GBM) is a malignant tumor of astrocytes that occurs in approximately 3.22 per 100,000 people1. Unfortunately, the underlying pathophysiology is poorly understood and physicians lack targeted treatments to offer patients1. In recent years, there has been a push to further classify GBM into discrete subtypes that…
Cancer Featured Abstracts

Single Nucleotide Polymorphisms (SNPs) and Amplification of Epidermal Growth Factor Receptor Contribute to Tumorigenesis of Glioblastoma

June 22, 2023 Taimur Hassan
Taimur Hassan Background: Glioblastoma multiform (GBM) is the most malignant brain tumor and has a median overall survivability (OS) of less than one year since diagnosis.1 Single-nucleotide polymorphisms (SNPs) and amplification of the epidermal growth factor receptor (EGFR) gene contribute to more than 50% of the cases where EGFR-related signaling…
Cancer Featured Abstracts

Osimertinib Exposure Induces Resistance via Upregulation of AXL Tyrosine Kinase Receptor in Non-Small Cell Lung Cancer

June 22, 2023 Sankirthana Malireddy
Sankirthana Malireddy Background: Lung cancer is one of the primary causes of mortality in those affected by cancer, non-small cell lung cancer (NSCLC) being the predominant form.1 This cancer is exacerbated by lifestyle factors such as smoking, and genetic factors such as mutations involving the epidermal growth factor receptor (EGFR).1…
Cancer