Targeting the Indoleamine 2,3-Dioxygenase Pathway to Suppress Pancreatic Ductal Adenocarcinoma Metastasis

Soumya Shekhar Introduction. Pancreatic ductal adenocarcinoma (PDAC) remains as one of the deadliest types of cancer, with 5-year survival rates remaining around 3% (1). PDAC tends to metastasize earlier than other types of cancer, so the efficacy of traditional first-line cancer treatments such as surgical resection and radiation therapy is…
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The Epigenetic Role of MicroRNA’s in Retinoblastoma Proliferation and Invasion through Targeting of the Wnt/Beta-Catenin Pathway

Varada Salimath  Introduction. Retinoblastoma is the most frequently occurring pediatric ocular cancer.1 It arises from mutation in both alleles of the tumor suppressor gene Rb1 on chromosome 13, which codes for the cell cycle regulating retinoblastoma protein (pRb).2 Symptoms include leukocoria, vision loss, strabismus, and hypopyon.3 Early detection and treatment…
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Lin28/let-7 Axis Plays A Key role in Regulating Aerobic Glycolysis and Cancer Progression in Hepatocellular Carcinoma via PDK1

Sonia Rao  Introduction.  Hepatocellular carcinoma (HCC) is the fifth leading cause of cancer in the world with a 5-year survival rate of only 5%, demonstrating the need for improved treatments1,2. Risk factors for HCC include alcohol consumption and diabetes, and it is usually a progression of cirrhosis1. All cancers exhibit…
Cancer Featured Abstracts

MYC Promotion of Oxidative Phosphorylation Enhances Chemotherapy Resistance in Triple-Negative Breast Cancer

Neha Pal Introduction. Triple-negative breast cancers (TNBCs) account for approximately fifteen percent of breast cancers, and they lack the presence of the estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2). Because targeted therapies rely on the presence of at least one of the previously mentioned…
Cancer Featured Abstracts