The Role of H. pylori in the Progression of Gastric Cancer Through Activation of the JAK/STAT Pathway and Sequential Inflammatory Response Elements

Sanjana Nayak Introduction. Gastric cancer is one of the leading causes of cancer-related death in the world, with the rate of incidence still high in East Asia1. H. pylori infection is the main risk factor, with the likelihood for infection increasing with greater age, higher BMI, and male sex2,3,4. H.…
Cancer Inflammation Microbiology

BRCA mutations and PARP inhibitors

Michael Longo Introduction. The breast cancer susceptibility genes BRCA1 and BRCA2 were originally identified as the genetic source of familial breast cancer 1,2 and have since been used to identify one’s own risk of breast cancer development. Carriers of BRCA1 mutations have a 72% chance of developing breast cancer; 69%…
Cancer

Mechanisms and Strategies to Overcome Aromatase Inhibitor Resistance in Estrogen-Positive Breast Cancer via the PI3K/AKT/mTOR Pathway

Jordan Han Introduction: Breast cancer accounts for up to 23% of all cancer deaths in postmenopausal women1. Estrogen-receptor positive breast cancers are still one of the most common types of breast cancer today, and are commonly treated by aromatase inhibitors or estrogen receptor inhibitors2. Aromatase inhibitors remain one of the…
Cancer