Understanding the Role of Active Receptor-Like Kinase 2 and Activin Receptor 1A in Fibrodysplasia Ossificans Progressiva: Progression and Therapeutic Prospects for Heterotopic Ossification
Steven Perez Background: FOP stands as an enigmatic genetic disorder, marked by HO formation and debilitating musculoskeletal abnormalities.1,6 The dysregulation of ACVR1, alias ALK2, precipitates an aberrant activation cascade, disrupting normal bone morphogenetic protein (BMP) signaling and promoting ectopic ossification.2 Current therapeutic options are limited, necessitating innovative approaches to mitigate…