Category: Lymphatics

Dual Versus Single Vascularized Lymph Node Transfer in Breast Reconstruction

July 7, 2026 Alexander Michael Bogdan
Alexander Michael Bogdan Background: Breast cancer-related lymphedema (BCRL) is a chronic complication of axillary surgery and radiation that can lead to persistent swelling, fibrofatty change, recurrent cellulitis, heaviness, and loss of function. Vascularized lymph node transfer (VLNT) is used in patients with more advanced disease, especially when conservative treatment has…
Engineering Medicine Featured Abstracts Lymphatics

RAAS Mediated TGF-β Signaling Drives Fibrosis and Lymphatic Dysfunction in Breast Cancer–Related Lymphedema: A Therapeutic Target

July 3, 2026 Shivam Pancholy
Shivam Pancholy Background: Secondary lymphedema is a chronic and progressive complication commonly associated with cancer treatment, particularly following lymphadenectomy and radiation therapy.2-4 The disease is characterized by impaired lymphatic drainage, persistent inflammation, extracellular matrix (ECM) deposition, and progressive fibrosis, all of which contribute to significant morbidity and decreased quality of…
Cancer Featured Abstracts Lymphatics

Translational Implications of Meningeal Lymphatic Dysfunction on Neuroinflammation and Cognitive Decline

July 1, 2026 Reginaldo Capati
Reginaldo Capati Background: The meninges have lymphatic vessels that exit the skull along the retroglenoid vein, sigmoid sinus, and meningeal portions of the pterygopalatine artery, draining to the deep cervical lymph nodes followed by the superficial cervical lymph nodes.1 The function of meningeal lymphatic vessels is to drain cerebrospinal fluid…
Lymphatics Neuroscience

Lymphangiocrine Signaling via the CXCL12-CXCR4 Axis: A Spatial Regulator of Post-Myocardial Infarction Cardiac Remodeling and Its Potential for Therapeutic Targeting

July 1, 2026 Shashank Bhagavatula
Shashank Bhagavatula Background: Cardiovascular diseases cause approximately 17.9 million deaths annually, projected to exceed 23.6 million by 2030.6 Myocardial infarction (MI) triggers irreversible cardiomyocyte loss followed by persistent inflammation and fibrosis that can progress to heart failure; while current treatments, including percutaneous coronary intervention, ACE inhibitors, and beta-blockers, address acute…
Cardiology Lymphatics

Postsurgical Lymphatic Regeneration: Potential of 9-cis-RA and VEGF-C Combined Therapy

July 1, 2026 Ryan Becka
Ryan Becka Background: Secondary lymphedema is a chronic, progressive disorder caused by lymphatic injury or obstruction and is most commonly associated with cancer surgery and radiation therapy in developed countries.1,2,3,4 It is characterized by impaired lymphatic drainage, protein-rich interstitial fluid accumulation, chronic inflammation, adipose deposition, and fibrosis.1,2,3,4 Current treatment consists…
Featured Abstracts Lymphatics

The Role of Lymphatic Drainage and Glymphatic Dysfunction in Neurodegenerative Conditions and Potential Therapeutic Strategies

July 22, 2025 Mindy Nguyen
Mindy Nguyen Background: Alzheimer’s Disease (AD) is the most common form of dementia and is characterized by slow and gradual loss of declarative episodic memory.1 Aging leads to higher susceptibility of neurodegeneration and reduced vasculature function. Diminished efflux of waste products from meningeal lymphatic vessels (mLVs) can lead to the…
Featured Abstracts Lymphatics Neuroscience

Synergistic Modulation of Cerebral Edema Drainage By Central Glymphatic And Peripheral Lymphatic Systems in Post-Ischemic Stroke Patients

June 23, 2022 Urenna Orazulike
Urenna Orazulike Introduction: An ischemic stroke occurs when blood circulation to the brain is reduced or blocked, such that cerebral neurons are deprived of oxygen and nutrients.1 Brain edema forms soon after the onset of vascular blockage and the ensuing interruption in cerebral blood flow. Recent studies have discovered that…
Cardiology Lymphatics