Metabolism – Proceedings of the Texas A&M Medical Student Grand Rounds

Isocitrate Dehydrogenase Enzyme Mutations in Glioblastoma Multiforme Metabolism and Cell Survival

May 31, 2022 Daniel Connors

Daniel Connors Introduction. Glioblastoma is an aggressive astrocyte-derived brain cancer with a poor prognosis. Survival in glioblastoma patients is typically prolonged for only a few months with intervention.1 In adult glioblastoma patients, mutations in IDH1/2 genes presage a better overall survival.5 IDH1mt patients have been shown to have longer survival…

Cancer Metabolism

Exercise As A Mechanism to Increase Per2 Expression in Type 2 Diabetics

August 2, 2021 Kacie Mitchell

Kacie Mitchell Introduction: Type 2 diabetes (T2D) is a highly prevalent metabolic disease characterized by insulin resistance.1 In 2015, it was estimated that 1 in 11 adults aged 20-79 were diagnosed with diabetes and over 90% of those were type 2.1 Underlying causes of T2D include obesity, caloric excess, and…

Endocrinology Metabolism

Increased Expression of MOTS-c Due to Physical Activity Improves Glucose Regulation in the Progression of Type 2 Diabetes Mellitus

July 30, 2021 Audrey Kelley

Audrey Kelley Introduction: Type 2 Diabetes Mellitus (T2DM) is the most common metabolic disease in the world, and is characterized by an insufficient response to insulin with subsequent glucose accumulation in the blood.1,2 High-fat diets contribute to the development and progression of the disease by downregulating the expression of glucose…

Metabolism