Yasmin Hammami Background: Neural tube defects (NTDs) remain a leading cause of neonatal mortality, occurring in 2 per 1,000 births globally and nearly 300,000 cases annually.1 Despite folic acid fortification, 40–50% of NTDs persist, underscoring the insufficiency of folate monotherapy.1,2 Folate-dependent methylation regulates the genes and cellular processes needed for…

Josh Botros  Background: Maple syrup urine disease (MSUD) is an autosomal recessive metabolic disorder caused by a deficiency of the branched-chain α-keto acid dehydrogenase (BCKD) complex, resulting in the accumulation of branched-chain amino acids (BCAAs).1 Current primary treatment through dietary restriction or liver transplantation improves survival but does not fully…