The Mechanism of Nervous System Damage by Zika Virus

Alexis Medders  Introduction. Zika virus (ZIKV) is part of the family Flaviviridae and is spread primarily by mosquitoes (Aedes aegypti and Aedes albopictus). VIKV is known to cross the blood-brain and placental barriers to cause damage to the central nervous system and can be vertically transmitted from an infected mother1.…
Microbiology

The Mechanism of Nervous System Damage by Zika Virus and the Role of Toll-like 3 Receptors

Michaela Marziale  Introduction. Zika virus (ZIKV) is a mosquito-borne virus that primarily infects human skin (dermal fibroblasts and epidermal keratinocytes), with the majority of infections being asymptomatic3. During 2015-2016 there was a ZIKV pandemic that lead to the World Health Organization (WHO) to declare a public health emergency of international…
Microbiology

The Role of the Gut Microbiome in Mediating Obesity

Connie Hsiao  Introduction.  Obesity is a condition characterized by excessive adipose tissue and increases an individual’s risk for health, social and mental issues. Obesity is a major issue in the United States, where more than one- third of Americans are clinically obese (BMI ≥ 30 kg/m2).[1] Environmental and genetic factors…
Microbiology

The Role of the Intestinal Microbiome in the Pathogenesis of Autistic Spectrum Disorder

Rachael Helpenstell Counts  Introduction.  Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by limited social communication skills and stereotypical behavioral patterns.1,2 Many ASD patients also have gastrointestinal (GI) symptoms.2 Because of the heterogeneity of ASD, it is difficult to identify a single cause. However, environment, especially the intestinal microbiome,…
Microbiology Neuroscience

Fecal Transplantation to Modulate Abnormal Gut Microbiota in Autism Spectrum Disorder Individuals

Christian Beltran  Introduction. Autism spectrum disorder (ASD) is a neurodevelopment disorder that presents with early deficits in social communication and unusual restricted and repetitive behaviors.1 It has been established that the gut microbiome differs between children with ASD with functional gastrointestinal disorders and neurotypical (NT) children functional gastrointestinal disorders.2,3 There…
Microbiology Neuroscience

Potential mechanisms of Zika Neuropathogenesis

George Bailey Introduction: Zika virus (ZIKV) is a single stranded positive RNA flavivirus originally thought only to cause mild illness that rarely needed treatment; however, in recent outbreaks it has been associated with severe neurological conditions such as Guillan-Barre and fetal microcephaly. Studies show that ZIKV utilizes different cell-surface receptors…
Microbiology Neuroscience