Neuroprotective Role of Adenosine A2A Antagonists in the Manifestation and Progression of Parkinson’s Disease

Michael Campos Introduction. Parkinson’s Disease is the result of progressive degeneration of the dopaminergic neurons in the Substantia Nigra.1 Cardinal features include resting tremor, bradykinesia, rigidity, and a variety of other motor and non-motor symptoms.2 The key molecular pathogenic mechanisms include neuroinflammation and oxidative stress, mitochondrial dysfunction, alpha-synuclein misfolding and…
Neuroscience

Mitochondrial Proteostasis of Cytosolic TDP-43 Protein Aggregates Mediates Mitochondrial Dysfunction in C9orf72 ALS

Eiline Cai Introduction. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive degeneration of upper and lower motor neurons.1 About 90% of diagnosed patients die within 5 years of onset.1 Currently, two medications have been approved for ALS treatment – riluzole and edaravone.1,2 Riluzole increases survival only by about 3…
Featured Abstracts Neuroscience

The Role of the Kynurenine Metabolism and β-Catenin Upregulation in Aerobic Exercise to Diminish Depression and Anxiety Symptoms

Anna Bergquist Introduction: Mental illness accounts for around 32.4% of the total number of years lived with a disability worldwide, with depression and anxiety disorders being the first and sixth leading causes of disability respectively.1 The NIH states that 7.1% of U.S. adults experienced major depressive disorder and 2.7% of…
Neuroscience

Neuronal excitability changes and possible target mechanism for therapeutic and prophylactic intervention of post-stroke epilepsy

Rodiyah Temi Ajala-Jabar Introduction. Post-stroke epilepsy (PSE) is the re-occurrence of two or more unprovoked seizures more than twenty-four hours apart, and at least one week after a patient experiences stroke.1, 2 PSE accounts for 10% of all epilepsy cases, diagnosed in up to 22% of patients after stroke and…
Featured Abstracts Neuroscience

Role of DNA Methylation in the Pathogenesis of and Choline Supplementation in the Treatment of Fetal Alcohol Spectrum Disorder

Rasik Jankay Introduction.  Fetal Alcohol Spectrum Disorder (FASD) is a leading cause of preventable intellectual disability which refers to the range of effects that can occur due to prenatal alcohol exposure. Typical manifestations in the child include facial anomalies such as short palpebral fissures, thin vermilion border, and smooth philtrum,…
Neuroscience

Calorie Restriction Promotes Myelin Formation by Activating AMP-Activated Protein Kinase: Implications for Multiple Sclerosis Treatment

Pranav Gadangi Introduction. Multiple sclerosis (MS) is a chronic, autoimmune disease of the central nervous system that leads to demyelination and neurodegeneration in nearly 200 patients per week1. The condition starts in a relapsing-remitting form for the first 10-15 years followed by a severe, progressive form that decreases life expectancy…
Featured Abstracts Neuroscience

PTK2-TBK1 Activation Impairs the Removal of TDP-43 Aggregates in the Pathogenesis of Amyotrophic Lateral Sclerosis

Lauren Fitzgerald  Introduction. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of upper and lower motor neurons and the most common adult-onset motor neuron disease.1 The mean age of onset is 55 years, and symptoms include denervation, muscle wasting, and weakness.2,3 Death from respiratory failure typically occurs 3-5 years…
Neuroscience