Category: Ophthalmology

Biomarkers from Tears may Provide Clarity on Thyroid Eye Disease Diagnosis, Disease State Progression, and Targeted Treatment Options

June 24, 2024 Rasha Bara
Rasha Bara Background: Thyroid Eye Disease (TED) is an autoimmune condition occurring in ~50% of Graves’ Disease patients.1 Disease status is defined by the clinical activity score (CAS), resulting in scores from 0 to 7. The active phase (CAS ≳ 3) is defined by conjunctiva swelling, redness, inflammation, and eyelid…
Engineering Medicine Featured Abstracts Ophthalmology

Visual Prosthetics for Vision Restoration for Retinal Degeneration

July 25, 2023 Paras Gupta
Paras Gupta Background: Retinal degeneration is initially associated with functional deficit and neuronal network programming that progresses to structural changes and heavy photoreceptor loss. After significant photoreceptor loss, innovative solutions such as neuroprotection, gene therapy, and cell therapy are no longer useful alone. Objectives: We explore visual prosthetics as an…
Engineering Medicine Ophthalmology

Meg3 (LncRNA) Knockdown as a Target for the Treatment of Post-Traumatic, Corneal Neovascularization

July 25, 2023 Ronald Alek Sperry
Ronald Alek Sperry Backgound: Corneal neovascularization is a condition characterized by ingrowth of blood vessels into the corneal tissue. Currently, treatment is progression-dependent because immature blood vessels depend on growth factors for proliferation while established blood vessels do not. This dictates that treatment be aimed at either the removal of…
Engineering Medicine Ophthalmology

Medium Wavelength Cone Opsin (MW-opsin) Modification of Light-Sensitive G-Protein Coupled Receptors (GPCRs) Increases Sensitivity by Signal Amplification of Photoreceptors

July 24, 2023 Ashutosh Tripathy
Ashutosh Tripathy Background: Retinitis pigmentosa, a rare genetic disease, causes deterioration of light-sensing cells in the retina, which leads to night vision loss, peripheral vision, and visual sharpness. The cure for this disease poses challenges in developing gene therapies. Optogenetics offers a solution by replacing faulty rhodopsin molecules and introducing…
Engineering Medicine Ophthalmology

Examining the Role of MALAT1 and Its Downstream Effectors in Regulating Retinal Vascularization in Retinopathy of Prematurity

June 20, 2022 Jasmine Peng
Jasmine Peng Introduction: Retinopathy of prematurity (ROP) is a spectrum of retinal pathologies, ranging from spontaneous regression to retinal detachment, and is a leading cause of childhood blindness worldwide1. A defining characteristic of ROP is neovascularization, a pathological over-vascularization of the retina mostly caused by changes in metabolism and oxygen…
Ophthalmology

Disrupted Photoreceptor Outer Segment Degradation Induces Retinal Pigment Epithelium Senescence and Complement Dysregulation in Age-Related Macular Degeneration

August 11, 2020 Zachary I. Richards
Zachary I. Richards  Introduction. Age-related macular degeneration (AMD) is the top cause of vision loss for those over 70.1 The disease presents with central photoreceptor loss and irreversible central blindness.1 Two types of AMD predominate, wet and dry. Wet AMD is a disease of neovascularization in the choroid, while dry…
Featured Abstracts Ophthalmology