Visual Prosthetics for Vision Restoration for Retinal Degeneration

Paras Gupta Background: Retinal degeneration is initially associated with functional deficit and neuronal network programming that progresses to structural changes and heavy photoreceptor loss. After significant photoreceptor loss, innovative solutions such as neuroprotection, gene therapy, and cell therapy are no longer useful alone. Objectives: We explore visual prosthetics as an…
Engineering Medicine Ophthalmology

Meg3 (LncRNA) Knockdown as a Target for the Treatment of Post-Traumatic, Corneal Neovascularization

Ronald Alek Sperry Backgound: Corneal neovascularization is a condition characterized by ingrowth of blood vessels into the corneal tissue. Currently, treatment is progression-dependent because immature blood vessels depend on growth factors for proliferation while established blood vessels do not. This dictates that treatment be aimed at either the removal of…
Engineering Medicine Ophthalmology

Medium Wavelength Cone Opsin (MW-opsin) Modification of Light-Sensitive G-Protein Coupled Receptors (GPCRs) Increases Sensitivity by Signal Amplification of Photoreceptors

Ashutosh Tripathy Background: Retinitis pigmentosa, a rare genetic disease, causes deterioration of light-sensing cells in the retina, which leads to night vision loss, peripheral vision, and visual sharpness. The cure for this disease poses challenges in developing gene therapies. Optogenetics offers a solution by replacing faulty rhodopsin molecules and introducing…
Engineering Medicine Ophthalmology

Examining the Role of MALAT1 and Its Downstream Effectors in Regulating Retinal Vascularization in Retinopathy of Prematurity

Jasmine Peng Introduction: Retinopathy of prematurity (ROP) is a spectrum of retinal pathologies, ranging from spontaneous regression to retinal detachment, and is a leading cause of childhood blindness worldwide1. A defining characteristic of ROP is neovascularization, a pathological over-vascularization of the retina mostly caused by changes in metabolism and oxygen…
Ophthalmology

Disrupted Photoreceptor Outer Segment Degradation Induces Retinal Pigment Epithelium Senescence and Complement Dysregulation in Age-Related Macular Degeneration

Zachary I. Richards ¬†Introduction. Age-related macular degeneration (AMD) is the top cause of vision loss for those over 70.1 The disease presents with central photoreceptor loss and irreversible central blindness.1 Two types of AMD predominate, wet and dry. Wet AMD is a disease of neovascularization in the choroid, while dry…
Featured Abstracts Ophthalmology