Month: September 2023
Somatodendritic 5-HT1A Autoreceptor Desensitization due to Selective Serotonin Reuptake Inhibitor (SSRI) Therapy for Depression
Mathew Pietz Introduction: Depression is a mood disorder and is highly prevalent in the United States. Mood disorders affect about 20% of the population while major depressive disorder (MDD) specifically affects almost 7% of the US population.2 Common symptoms of depression include insomnia, lethargy, unexplained pain, GI symptoms, and headaches.3…
The Role of GABA in Alcohol Use Disorders
Minhal Zaidi Alcohol use disorders are a result of heightened pleasure from repeated alcohol drinking behavior. 6 There are genetic components and environmental factors linked to alcohol use disorder. There is genetic heterogeneity in the risk of developing alcohol dependence, with different genetic loci contributing to the risk. 6 The…
Leveraging Dysfunctional Mechanisms in Familial Hypertrophic Cardiomyopathy for Therapeutic Use in Patients with MyBPC Truncation Mutations
Kieran Paddock Introduction: Familial hypertrophic cardiomyopathy (HCM) is a genetic disease characterized by hypertrophy of the ventricular wall, causing obstruction of the left ventricular outflow tract (LVOT).1–3 It is the most common cause of sudden cardiac death in athletes.2 It is predominantly due to mutations in MYBPC3 for myosin binding…