Category: Uncategorized
PARP Inhibition as a Promising Option to Treat RB1 Deficient Osteosarcoma, Which Demonstrates Marked Vulnerability
George Li Introduction: Osteosarcoma is the most common primary bone malignancy in pediatric patients that often aggressively metastasizes if improperly managed. 1 Current early phase clinical trials are focused on modification of current antineoplastic agents, but have only managed to demonstrate that they are tolerable with questionable efficacy. 2 Poly-ADP-Ribose-Polymerase…
Mitigating Adverse Side Effects of Atypical Anti-Psychotic Drugs by Targeting the Histamine, H3, Receptor Subtype
Sabine Itani Introduction: Atypical antipsychotic drugs play a key role in the treatment of schizophrenia, bipolar disorder, and depression.1 In the US, over 50% of adults over the age of 70 use anti-psychotic drugs.2 Weight gain has been identified as one of the major side effects caused by atypical antipsychotic…