Author: Taimur Hassan

Single Nucleotide Polymorphisms (SNPs) and Amplification of Epidermal Growth Factor Receptor Contribute to Tumorigenesis of Glioblastoma

June 22, 2023 Taimur Hassan
Taimur Hassan Background: Glioblastoma multiform (GBM) is the most malignant brain tumor and has a median overall survivability (OS) of less than one year since diagnosis.1 Single-nucleotide polymorphisms (SNPs) and amplification of the epidermal growth factor receptor (EGFR) gene contribute to more than 50% of the cases where EGFR-related signaling…
Cancer Featured Abstracts

Effects of Blocking PTEN in Central Nervous System Axons on Axon Regeneration and Functional Outcomes Following Spinal Cord Injury

June 22, 2023 Tarun Sontam
Tarun Sontam Background: Spinal cord injury (SCI) is a form of traumatic and/or degenerative damage to the spinal cord that dramatically impacts quality of life and can ultimately lead to severe functional effects such as loss of mobility and/or sensation. Around the world, there are about 930,000 new cases of…
Featured Abstracts Neuroscience

The role of TnT-I79N in the Upregulation of Calcium Channels Leading to Hypertrophic Cardiomyopathy Associated Sudden Cardiac Death Risk

June 22, 2023 Shourya Kashyap
Shourya Kashyap Background: Hypertrophic Cardiomyopathy (HCM) is a monogenic inherited cardiac disease that has a prevalence of 1/500 and is present in over 60 countries in all continents.1,2The disease is caused by a genetic mutation (mostly missense) that disrupts the genetic coding of cardiac sarcomeres.1While advanced cases are clinically diagnosable…
Cardiology Featured Abstracts

The Use of Conductive Biomaterials For Cardiac Tissue Engineering To Treat Post Myocardial Infarction Cardiac Fibrosis

June 22, 2023 Steven Maxwell
Eshan Sayani Background: Myocardial infarction (MI) is a common condition that can lead to cardiac fibrosis and heart failure1,2,3,4,5,6. Current treatments have limitations in targeting fibrotic tissue and there are no reliable biomarkers to predict the development or severity of fibrosis1,2,3. The lack of effective treatments for established post-MI cardiac…
Cardiology

Osimertinib Exposure Induces Resistance via Upregulation of AXL Tyrosine Kinase Receptor in Non-Small Cell Lung Cancer

June 22, 2023 Sankirthana Malireddy
Sankirthana Malireddy Background: Lung cancer is one of the primary causes of mortality in those affected by cancer, non-small cell lung cancer (NSCLC) being the predominant form.1 This cancer is exacerbated by lifestyle factors such as smoking, and genetic factors such as mutations involving the epidermal growth factor receptor (EGFR).1…
Cancer