Renal Genitourinary – Proceedings of the Texas A&M Medical Student Grand Rounds

HMGB1-Rage Signaling as a Driver of Lymphatic Remodeling in Post-Traumatic Acute Kidney Injury

July 1, 2026 Gerik Grabowski

Gerik Grabowski Background: Acute Kidney Injury (AKI) is a multifactorial condition resulting from impaired kidney function which can ultimately impact multiple organ systems including the cardiovascular, GI, and pulmonary systems.1,2 AKI is a widely prevalent condition affecting 10-15% of hospitalized patients globally.1 Trauma results in AKI through the upregulation of…

Featured Abstracts Renal Genitourinary

Implications of the Urinary Microbiome in Urinary Tract Infections

July 25, 2023 Rijul Nanda

Rijul Nanda Background: Urinary tract infections (UTIs) are one of the most common bacterial infections around the world, affecting over 150 million people yearly with an estimated cost of UTIs being $2.8 billion1. There is a paucity of research to discover novel strategies for UTI outside of antibiotics, especially therapies…

Dysregulation in Chronic Kidney Disease and the Need for Fully Functional Renal Replacement Therapy

June 28, 2022 Joshua Moskow

Joshua Moskow Introduction. The kidneys are a main source of homeostatic control in the body. Chronic kidney disease (CKD) has a number of criteria but all represent a decline in kidney function. The most common causes are diabetes and hypertension1,2. In addition to a failing glomerular filtration barrier, the kidneys…

Engineering Medicine Renal Genitourinary

The Role of Protein-Bound Indoxyl Sulfate in the Development of Cognitive Dysfunction in Patients with Chronic Kidney Disease (CKD)

June 28, 2022 Adnan Khan

Adnan Khan Introduction. Chronic Kidney Disease (CKD) is defined in patients with a glomerular filtration rate less than 60 mL/min/1.73 m2. Patients typically develop a myriad of complications including, but not limited to, edema, anemia, uremia, hyperkalemia, and heart disease. An important neurological complication of CKD is the three times…

Engineering Medicine Renal Genitourinary

Renin-Angiotensin System Induced Production of TNF-α Mediates the Exaggerated Activation of M1 Macrophages and Further Pathogenesis in Diabetic Nephropathy

June 22, 2022 Braden Sims

Braden Sims Introduction. Improper management of Diabetes Mellitus (DM) can lead to the progression of Diabetic Nephropathy (DN), which is the leading cause of end-stage kidney disease in most developed countries, including the United States.1 Progression of DN and worsening renal function have been strongly associated with the interplay and…

Immunology Renal Genitourinary

Targeting Beta-Catenin in T Cells in Polycystic Kidney Disease

June 22, 2022 Shalini Sharma

Shalini Sharma Introduction: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a single gene disorder, of the PKD1 gene, affecting over 12 million people today.1 It is characterized by large noncancerous cysts on the patient’s kidneys associated with renal tubular dysfunction, hypertension, renal pain, increased renin production, as well as other…

Renal Genitourinary

The Role of Polycystin 1 and Polycystin 2 (PC1/PC2) in Calcium Intake and Pathogenesis of Autosomal Dominant Kidney Disease

August 18, 2021 Tarek Dawamne

Tarek Dawamne Introduction. Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common potentially lethal single gene disorder. ADPKD is often associated with renal cysts that cause increased kidney malfunction such as hematuria, flank pain, kidney stones, carcinoma, in addition to other cardiovascular abnormalities1. Methods. Many sources were reviewed to…

Featured Abstracts Renal Genitourinary

The Role of mtROS-Induced Microvascular Dysfunction in the Progression of Chronic Kidney Disease

August 2, 2021 Yi Hsuan Ku

Yi Hsuan Ku Introduction. Kidney disease (KD) represents the ninth leading cause of death in the United States, and a key risk factor is diabetes1. There is currently no cure for chronic KD (CKD), and CKD patients can only receive supportive therapy2. CKD patients are more likely to die from…

Renal Genitourinary