Jonathon Cummock  Introduction: Alzheimer’s disease (AD) is a progressive, debilitating neuropsychiatric disorder characterized by multifaceted decline in cognitive and behavioral functions1, 11. Key neuronal pathology includes amyloid-beta plaques and/or neurofibrillary tangles1, 11. A well-known feature of AD is the marked reduction and death of cholinergic neurons in the basal forebrain…

Esra Gumuser Introduction. Alcohol Use Disorder affects the United States both economically, with excessive binge drinking costing the U.S. $249 billion in 2010 alone1, and in mortality, being responsible for over 30,000 deaths in the 20142.  Long-term alcohol use is known to affect nearly every organ system primarily through epigenetic…

Jonathon Cummock  Introduction: Alzheimer’s disease (AD) is a progressive, debilitating neuropsychiatric disorder characterized by multifaceted decline in cognitive and behavioral functions1, 11. Key neuronal pathology includes amyloid-beta plaques and/or neurofibrillary tangles1, 11. A well-known feature of AD is the marked reduction and death of cholinergic neurons in the basal forebrain…

Christina Phan Introduction: Alzheimer’s disease (AD) is a type of dementia that typically occurs in adults older than 65 years of age,characterized symptomatically with the progressive loss of cognitive function and psychiatric manifestations. The depositions of plaques consisting of insoluble amyloid beta (AB) fibrils, are one of the major pathological…