Circadian Rhythms – Proceedings of the Texas A&M Medical Student Grand Rounds

In Pancreatic Islets from Type 2 Diabetes Patients, the Dampened Circadian Oscillators Lead to Reduced Insulin and Glucagon Exocytosis

June 21, 2023 Brock Jones

Brock Jones Background: Type 2 Diabetes Mellitus (T2D) is a disease resulting from decreased insulin sensitivity within the body mainly due to lifestyle choices related to diet and exercise.1 T2D seems to mainly stem from lifestyle, with a high caloric and high glycemic diet with insufficient exercise increasing the rate…

Role of Circadian Rhythm on Chronic Wound Healing via Neuronal PAS Domain Protein 2 (Npas2) Downregulation

June 6, 2023 Anuj Gupta

Anuj Gupta Background: Wound healing is a complex process that often can be impaired by various disease mechanisms, such as diabetes and cancer. This can result in chronic wounds that cannot heal and recover properly.1 They can affect roughly 1% to 2% of the general population and can lead…

Circadian Rhythms Featured Abstracts Wound Healing

The Role of Endoplasmic Reticulum Stress and Circadian Clock Genes on Glucose Homeostasis of Shift Workers

June 22, 2022 Meghana Vankina

Meghana Vankina Introduction. The circadian rhythm is an endogenous rhythmic pattern that is present in most organisms. In mammals, the central brain clock is within the suprachiasmatic nucleus and consists of a 24-hour autoregulatory feedback loop1. Disruption of circadian rhythms has been linked to various cardio-metabolic disorders such as diabetes1.…

Circadian Rhythms

Circadian Rhythm Impact on Entry, Progression, Secondary & Long-term Effects of SARS-CoV-2

June 22, 2022 Revanth Vadlamudi

Revanth Vadlamudi Introduction. This study investigates the potential influence of circadian rhythms and clock genes on the infection and pathogenesis of SARS-CoV-2 to preface future targets for prophylaxis, chronotherapeutics during infection, and long-term secondary illness. SARS-CoV-2 is a pneumotropic RNA beta-coronavirus of zoonotic origin; human transmission occurs primarily via respiratory…

Circadian Rhythms Microbiology

Circadian Rhythm Disruption Due to Degradation of Melanopsin Containing Intrinsically Photosensitive Retinal Ganglionic Cells (mRGCs) in Individuals with Parkinson Disease (PD)

June 22, 2022 Myla Sykes

Myla Sykes Introduction: PD is caused by alpha-synuclein aggregates in the sub-cortical basal ganglia. Cardinal symptoms of PD include a triad of pill-rolling/resting tremor, bradykinesia, and cogwheel rigidity1,2. In addition, sleep disorders often manifest early in the progression of the disease. mRGCs convey light signals from the retina to the…

Circadian Rhythms Neuroscience

The Cardio-Protective Role of the Clock Gene Following Myocardial Infarction

June 21, 2022 Daniaal Saeed

Daniaal Saeed Introduction: Myocardial infarction (MI) results from prolonged ischemia to the myocardium of the heart caused by stenosis of the coronary arteries that perfuse the heart.1,2 Despite the fact that MI is an acute event, many long-term lifestyle factors such as environment, diet, genetics, exercise habits, and even gender…

Cardiology Circadian Rhythms

Targeting Circadian Clock Associated Genes NR1D1 and Clock to Reduce Risks of Sudden Cardiac Death (SCD)

June 20, 2022 Christine Ramjee

Christine Ramjee Introduction: Sudden Cardiac Death (SCD) is death that occurs within one hour of the loss of heart function or adequate perfusion to the body. The etiology of SCD is due to either acquired or genetic cardiovascular disease, but most commonly, any patient with prior cardiac dysrhythmias is at…

Circadian Rhythms