Featured Abstracts – Page 6 – Proceedings of the Texas A&M Medical Student Grand Rounds

P2Y12 Receptor Inhibitors Increasing the Efficacy of Post-Acute Myocardial Infarction Treatment

June 21, 2023 Madison Beall

Madison Beall Background: Acute myocardial infarction (AMI), also known as a heart attack, is the result of a limited or complete blockage of blood flow to the heart leading to myocardial necrosis.1 AMIs are treated by using a dual therapy consisting of a P2Y12 receptor inhibitor and aspirin, a cyclooxygenase…

Cardiology Featured Abstracts

Mesenchymal Stem Cells Improve Recovery from Facial Nerve Palsy by Promoting M2 Macrophage Polarization via Akt/FoxO1 Pathway

June 21, 2023 Aaron Mackie

Aaron Mackie Background: Facial nerve palsy is the partial or complete inability to move the affected side of the muscles of facial expression through damage to the facial nerve.1 There are various causes of facial nerve palsy including idiopathic facial paralysis, infection, neoplasm, developmental, metabolic, toxic, trauma, and iatrogenic.2 Facial…

Featured Abstracts Immunology

Role of Epstein Barr Virus in the Development of Multiple Sclerosis

June 21, 2023 Livia George

Livia George Background: Multiple Sclerosis (MS) is a chronic, progressive disease of the central nervous system with inflammation and demyelination of nerves. Although the pattern of symptoms can vary, common initial symptoms include visual deficits related to retrobulbar neuritis, paresthesia, and isolated sensory and motor symptoms.1 Although the exact cause of…

Featured Abstracts Microbiology

Hypoxia-Induced Resistance of Triple Negative Breast Cancer (TNBC) to Chemotherapy and Anti-PD-1 Therapy

June 21, 2023 Lexi Goehring

Lexi Goehring Background: Breast Cancer is the second most common cancer affecting women globally. While breast cancer generally has a high survival rate, Triple Negative Breast Cancer is a subtype that has a 50% recurrence rate in the first three to five years after diagnosis, and metastatic TNBC has a…

Cancer Featured Abstracts Immunology

Vitamin D Inhibits the Pro-Tumorigenic Functions of Cancer-Associated Fibroblasts in Colorectal Cancer

June 21, 2023 Lauren Wilkin

Lauren Wilkin Background: Colorectal cancer (CRC) is the third most common cancer and the second most deadly cancer in the United States, thus improvements in treatment are of increasing interest.1 The current treatment for stage I and II CRC is surgical resection, but once the cancer has metastasized, indicating stage…

Cancer Featured Abstracts

Fusobacterium nucleatum and Its Role in Modulating Autophagy in Colorectal Cancer

June 21, 2023 Laura Kim

Laura Kim Background: Colorectal cancer is the collective term for colon and rectal cancer. It is the second most lethal cancer and the third most common cancer worldwide.1,2,3 Right now, the most effective treatment for these patients is to use standard chemotherapy, typically 5-fluorouracil and oxaliplatin.2 These patients are initially…

Cancer Featured Abstracts Microbiology

The Role of Dysregulated Signaling Pathways In The Development of Hepatocellular Carcinoma

June 21, 2023 LaShawn Oyibo

LaShawn Oyibo Background: Hepatocellular carcinoma (HCC) is a primary liver cancer that develops from hepatocytes, which are the liver’s parenchymal cells.1 It is the most common primary liver cancer and is also the fifth most common type of cancer, accounting for almost 10% of all cancer cases.2 Current treatments for…

Cancer Featured Abstracts Hepatology

Blocking VISTA as a Target for Cancer Immunotherapy in Triple-Negative Breast Cancer

June 21, 2023 Kristen Downey

Kristen Downey Background: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with limited treatment options due to its lack of expression of the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2.1 The average survival rate of TNBC is around ten months with a…

Cancer Featured Abstracts Immunology

The Role of Immune Checkpoint Blockade Combinational Therapy in Remodeling the Immunosuppressive Microenvironment in the Treatment of Glioblastoma

June 21, 2023 Matthew Kenny

Matthew Kenny Background: Glioblastoma (GBM) is the most common primary tumor of the central nervous system in adults.1-4 The prognosis is poor, with the median survival averaging 14 months after diagnosis and the overall survival of patients beyond five years being less than 5%.3 Current treatment of GBM is combinational therapy…

Cancer Featured Abstracts Immunology

The Role of STING Agonism In Enhancing the Sensitivity of PARP Inhibitors in the Treatment of BRCA1/2 Deficient Breast Cancer

June 21, 2023 Katie De Jong

Katie De Jong Background: Breast cancer is the second most common cancer worldwide and the most frequently diagnosed female cancer, with one in eight women being diagnosed with breast cancer.1 BRCA 1 and BRCA 2, loss-of-function mutations for two genes that are crucial in DNA damage response, are found in…

Cancer Featured Abstracts