Elucidating IL-17 Signaling Involvement in the Pathogenesis of Alcoholic Liver Disease and Hepatocellular Carcinoma

Kieu Pham Introduction: Hepatocellular carcinoma (HCC) is the most common primary liver cancer.1 High alcohol intake has been linked to alcoholic liver disease (ALD), cirrhosis, and HCC.2 Because HCC usually occurs in patients suffering from known liver diseases like ALD, diagnosing HCC typically occurs through surveillance.2 Mechanistically, alcohol induces the…
Hepatology Neuroscience

Noradrenergic Hyperactivity and Resulting Denervation Explains Key Aspects of Non-Alcoholic Fatty Liver Disease (NAFLD) Pathology

Glori Das Introduction: An estimated 25% of the global population suffers from Non-Alcoholic Fatty Liver Disease (NAFLD)1. NAFLD is a progressive condition characterized by hepatocyte lipid accumulation (HLA) and fibrosis in its more advanced stages. Multiple pathways controlled by noradrenergic (NAergic) signaling have been implicated in NAFLD pathogenesis2,3,4. The goal…
Hepatology

Targeting the Sct/SR/TGF-β1 Axis to Delay Fibrosis in Primary Sclerosing Cholangitis

Kendal Updike Introduction. Primary Sclerosing Cholangitis (PSC) is a cholestatic liver disease affecting bile modification due to damage to cholangiocytes and intra- and extra-hepatic bile ducts1-3. Cholangiocytes are the only cell type in the liver that secrete secretin and express the G-protein coupled secretin receptor3. Through an autocrine mechanism, secretin…
Featured Abstracts Hepatology