Hepatology – Proceedings of the Texas A&M Medical Student Grand Rounds

Inhibition of the JNK/MAPK Pathway in Treatment of Acetaminophen Induced Liver Injury

June 22, 2023 Emily Minner

Emily Minner Background: Acetaminophen is the most used over-the-counter analgesic in the United States.1 Without careful review of the active ingredients in a drug, it can be easy to accidentally ingest a toxic amount of acetaminophen.1 Acetaminophen overdose is the result of 56,000 emergency visits, 2,600 hospitalizations, and 500 deaths…

Engineering Medicine Hepatology

The Role of Dysregulated Signaling Pathways In The Development of Hepatocellular Carcinoma

June 21, 2023 LaShawn Oyibo

LaShawn Oyibo Background: Hepatocellular carcinoma (HCC) is a primary liver cancer that develops from hepatocytes, which are the liver’s parenchymal cells.1 It is the most common primary liver cancer and is also the fifth most common type of cancer, accounting for almost 10% of all cancer cases.2 Current treatments for…

The Combination of Radiofrequency Ablation with Chemotherapy May Improve Hepatocellular Carcinoma Patient Outcomes

June 21, 2023 Jacob Abell

Jacob Abell Background: Hepatocellular carcinoma (HCC) is the 6th most common cause of cancer worldwide with 700,000 new cases each year and the average survival rate is 19.6% in the United States.¹ The most common primary malignancy of the liver, HCC significant risk factors include chronic alcohol consumption, viral infections,…

Cancer Featured Abstracts Hepatology

Elucidating IL-17 Signaling Involvement in the Pathogenesis of Alcoholic Liver Disease and Hepatocellular Carcinoma

June 20, 2022 Kieu Pham

Kieu Pham Introduction: Hepatocellular carcinoma (HCC) is the most common primary liver cancer.1 High alcohol intake has been linked to alcoholic liver disease (ALD), cirrhosis, and HCC.2 Because HCC usually occurs in patients suffering from known liver diseases like ALD, diagnosing HCC typically occurs through surveillance.2 Mechanistically, alcohol induces the…

Hepatology Neuroscience

Noradrenergic Hyperactivity and Resulting Denervation Explains Key Aspects of Non-Alcoholic Fatty Liver Disease (NAFLD) Pathology

May 31, 2022 Glori Das

Glori Das Introduction: An estimated 25% of the global population suffers from Non-Alcoholic Fatty Liver Disease (NAFLD)1. NAFLD is a progressive condition characterized by hepatocyte lipid accumulation (HLA) and fibrosis in its more advanced stages. Multiple pathways controlled by noradrenergic (NAergic) signaling have been implicated in NAFLD pathogenesis2,3,4. The goal…

Hepatology

The Role of Kupffer Cell Apoptosis in the Pathogenesis of Hepatic Ischemia-Reperfusion Injury During Liver Transplantation

May 31, 2022 Erin Cha

Erin Cha Introduction. In the world, 25% of the population has risk factors for liver disease with over 800,000 deaths from liver cancer.1,2 Amidst an organ shortage, when liver transplantation is often the only therapy for end-stage liver disease, the need for successful transplants is crucial.1,2 One of the main…

Hepatology Immunology

Targeting the Sct/SR/TGF-β1 Axis to Delay Fibrosis in Primary Sclerosing Cholangitis

August 5, 2021 Kendal Updike

Kendal Updike Introduction. Primary Sclerosing Cholangitis (PSC) is a cholestatic liver disease affecting bile modification due to damage to cholangiocytes and intra- and extra-hepatic bile ducts1-3. Cholangiocytes are the only cell type in the liver that secrete secretin and express the G-protein coupled secretin receptor3. Through an autocrine mechanism, secretin…

Featured Abstracts Hepatology