Category: Microbiology

The Role of Papain-Like Protease (Plpro) Domain of Nsp3 in Coronavirus Replication and Evasion of Host Immunity

June 20, 2022 Noah McNally
Noah McNally Introduction. Sars-CoV-2 (severe acute respiratory syndrome coronavirus) has become world famous as the causative agent of the COVID-19 disease.1 According to the World Health Organization, there have been over 346 million confirmed cases of COVID-19 infections worldwide, as of January 2022.2 This pandemic has ushered in a plethora…
Microbiology

Propionic Acid and Gut Dysbiosis: Therapeutic Targets for Autism Spectrum Disorder

June 16, 2022 Sloan Long
Sloan Long Introduction. Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex etiology, involving many environmental and genetic risk factors.1 The term “spectrum” describes the wide range of clinical presentations and severity, including deficits in communication and social interaction, restricted interests, and repetitive behaviors.1 Additionally, children with autism frequently…
Microbiology Neuroscience

Preformed Cross-Reactive Antibodies to Conserved Epitopes of COVID-19 May Aid in Designing Pan-Coronavirus Vaccines

June 12, 2022 Christopher Janssen
Christopher Janssen Introduction: COVID-19, the disease caused by SARS-CoV-2, is a global pandemic that has killed at least 5.7 million people and infected 385 million as of February 20221. Despite the successful creation and administration of 11.2 billion vaccines, antibodies generated from these vaccines have demonstrated reduced neutralization of recent…
Featured Abstracts Immunology Microbiology

Parabens as an Avenue for Prophylaxis of Thrombosis in Lemierre’s Syndrome

June 6, 2022 Mitchell Clark
Mitchell Clark Introduction & Hypothesis: Fusobacterium species, especially F. necrophorum, are the causative pathogens of Lemierre’s Syndrome (LS), which is characterized by disseminated intravascular coagulation and septic emboli.1,2 First-line treatment consists of aggressive antibiotic cocktails; the use of anticoagulants remains controversial, and might increase mortality by creating surgical complications.1,2 How…
Cardiology Featured Abstracts Microbiology

Exploration of Novel Anti-Quorum Sensing Compounds in Pseudomonas Aeruginosa Inhabited Cystic Fibrosis Patients

June 1, 2022 Karan Hooda
Karan Hooda Introduction. Cystic Fibrosis (CF) is a genetic disorder in which there is a deletion of F508 in the cystic fibrosis transmembrane conductance regulator gene (CFTR).1 This leads to mucus buildup and dehydration of respiratory airway surfaces, providing the optimal environment for pathogens to inhabit.2 Pseudomonas aeruginosa is a…
Microbiology Respiratory