Aging – Proceedings of the Texas A&M Medical Student Grand Rounds

Cellular Senescence Is Associated with Phenotypic Changes that Promote Inflammation and Aging

June 27, 2022 Emily Lo

Emily Lo Introduction: Cellular senescence is a cell stage associated with DNA damage in which a cell can no longer replicate and gains resistance to apoptosis1. Senescent cells secrete an array of inflammatory cytokines and chemokines, including TNF-alpha, IL-6, and IL-81. Accumulation of senescent cells and their associated inflammation is…

The Role of Lipid-Droplet-Accumulating Microglia in Driving Neuroinflammation and Alzheimer’s Disease in the Aged Brain

August 4, 2021 Ambeka Rajvanshi

Ambeka Rajvanshi Introduction: Alzheimer’s Disease (AD), the most common cause of dementia, affects ~40 million people worldwide.1 Approximately 90% of AD cases result from mutations in Apolipoprotein (ApoE) E3 and E4, genes associated with proteins involved in lipid transport.1,2 Increased ApoE4 expression is associated with microglial dysfunction, neurodegeneration, and microglial…

Aging Featured Abstracts Inflammation Neuroscience

Targeting the NO-cGMP-PKG Signaling Pathway and Phosphorylation of Titin as a Novel Treatment for HFpEF Patients

July 30, 2021 Jesper Jiang

Jesper Jiang Introduction. Heart failure (HF) is a clinical syndrome that disproportionately affects older individuals. Heart failure with preserved ejection fraction (HFpEF), where the left ventricular ejection fraction is greater than 50%, is the most common form of HF and accounts for at least 50% of all diagnosed HF.1-4 Age…

Aging Cardiology

Reversing Cellular Senescence in Satellite cells by Targeting P16INK4a-Inducing Pathways

July 2, 2019 William Choi

William Choi Introduction. Sarcopenia is an age-related process with a loss of function due to atrophy of muscle mass. Skeletal muscle accounts for nearly 40% of body mass and its decay can progress as individuals enter later stages of their lives. It can be debilitating on individuals, impairing normal routines…

Aging

ROS Production by Dysfunctional Mitochondria Leads to Cell Senescence and Bone Aging

July 2, 2019 Roma Bhandarkar

Roma Bhandarkar Introduction. Some damaged cells display cellular senescence, which is a stress response that results in permanent cell cycle arrest 2. Senescent cells secrete chemicals known as senescence-associated secretory phenotype (SASP) that drive pathologies associated with aging, such as osteoarthritis 3. Osteoarthritis is a chronic disease characterized by degeneration…

Aging Orthopedics

Prospect of Anti-Inflammatories in the Treatment and Prevention of Late-Life Depression

July 19, 2018 Ty Fields

Ty Fields Introduction. The link between inflammation and mental health disease has been an exciting development, prompting an outpouring of research analyzing the extent and nature of its involvement. While this link is most robustly understood and supported for depression, there are differences within sub-categories of depression that have yet…

Aging Inflammation

Mutation in Complement Factor H and its Contribution to the Development of Age-Related Macular Degeneration

July 9, 2018 Jake Portillo

Jake Portillo Introduction. Age related Macular Degeneration (AMD) is the leading cause of blindness in the United States, and affects upwards of 50 million individuals worldwide1,2. AMD is a complex disease with an etiology that is still not well understood. It is a disease of chronic inflammation in the eye,…

Aging Featured Abstracts

Retinal Pigment Epithelium Repair by Transplanting Umbilical Derived Cells: Mechanism and Therapeutic Potential for Age-Related Macular Degeneration

July 9, 2018 Olivia Moharer

Olivia Moharer Age-related macular degeneration (AMD) is the leading cause of blindness in elderly people1. The macula is the area of central vision and contains the retinal pigment epithelium (RPE) layer whose key function is phagocytosis of the photoreceptor outer segment (POS). Advancing age and genetic mutations in MerTK predispose…

Aging