ROS Production by Dysfunctional Mitochondria Leads to Cell Senescence and Bone Aging

Roma Bhandarkar ¬†Introduction. Some damaged cells display cellular senescence, which is a stress response that results in permanent cell cycle arrest 2. Senescent cells secrete chemicals known as senescence-associated secretory phenotype (SASP) that drive pathologies associated with aging, such as osteoarthritis 3. Osteoarthritis is a chronic disease characterized by degeneration…
Aging Orthopedics

Retinal Pigment Epithelium Repair by Transplanting Umbilical Derived Cells: Mechanism and Therapeutic Potential for Age-Related Macular Degeneration

Olivia Moharer Age-related macular degeneration (AMD) is the leading cause of blindness in elderly people1. The macula is the area of central vision and contains the retinal pigment epithelium (RPE) layer whose key function is phagocytosis of the photoreceptor outer segment (POS). Advancing age and genetic mutations in MerTK predispose…
Aging