Category: Diabetes

Dual-Hormone-Closed-Loop Systems (DHCLs) in the Treatment of Type I Diabetes

June 24, 2024 Jamen Cannon
Jamen Cannon Background. Type 1 diabetes (T1D) is an autoimmune disorder in which the immune system attacks the β-cells of the pancreas1. These cells are responsible for insulin production, which lowers blood glucose levels, in part, by increasing cellular glucose uptake, increasing glycogenesis, decreasing glycogenolysis and gluconeogenesis, and inhibiting Glucagon…
Diabetes Engineering Medicine Featured Abstracts

Role of Rac1 in Mitochondrial Damage Exacerbating Diabetic Retinopathy

June 12, 2024 Danny Varghese
Danny Varghese Background:  Diabetic retinopathy (DR) is a leading cause of vision impairment among adults globally, with prevalence rates expected to rise alongside increasing diabetes incidence.1 This condition results from prolonged hyperglycemia and dyslipidemia, leading to oxidative stress and mitochondrial damage within the retinal microvascular endothelium.1,2,3 Vision loss caused by…
Diabetes Featured Abstracts

Targeting Mineralocorticoid Signaling in the Treatment of Obesity and Diabetes-Associated Coronary Microvascular Disease in Women

June 12, 2024 Abigail Singer
Abigail Singer Background: Coronary Microvascular Disease (CMD) is a non-obstructive coronary artery disease characterized by vasospasms, endothelial damage, and ischemia1. There is a higher incidence in women, with time of onset usually coinciding with menopause, suggesting a sex-specific pathology2,3,4. It is known that CMD is associated with impairment of estrogen-mediated…
Cardiology Diabetes Featured Abstracts

Healing Potential: Enhancing Angiogenesis with induced Mesenchymal Stem Cell release of HIF1α/VEGF in Diabetic Foot Ulcer Therapy

June 5, 2024 Vivanna Nguyen
Vivanna Nguyen  Background: Currently, approximately 11.6% of Americans have been diagnosed with diabetes and this number continues to rise at an alarming rate.1 Diabetic foot ulcers (DFU) are a common complication of DM that are difficult to treat due to impaired wound healing as a result of hyperglycemia, peripheral arterial…
Diabetes Endocrinology