The NLRP3 Inflammasome: a Factor in Alzheimer’s Disease Pathogenesis and a Potential Therapeutic Target

Aleksandr Pereverzev Introduction. Alzheimer’s disease (AD) is the most common type of dementia1 and is characterized by amyloid-β (Aβ ) plaques, tau tangles, brain atrophy, and neuroinflammation2. The most accepted model of disease progression is the “amyloid-β cascade hypothesis” which identifies Aβ  deposits as the main cause of neurologic dysfunction1.…
Featured Abstracts Neuroscience

Epigenetic Therapeutic Intervention in Targeting Cytomegalovirus Latency and Reactivation Regulated by Bromodomain Proteins

Anushah Mirza Introduction. Cytomegalovirus (CMV) is from the family of beta-herpesvirus and is transmitted through bodily fluids.1,2 CMV can cause a broad range of serious disease like end organ failure.3 CMV is a latent virus whose reactivation is triggered by IL-6 and extracellular signal-regulated kinase (ERK)- mitogen activated protein kinase…
Featured Abstracts Microbiology

The Use of Asciminib to Inactivate BCR-ABL1 Through A Myristoyl Site Locking the BCR-ABL1 Protein into An Inactive Conformation in Patients with Resistant Chronic Myeloid Leukemia

Stephen Kwong Introduction: Chronic myeloid leukemia (CML) is a neoplasm that affects myeloid lineage blood cells1. In the US, CML affects 1-2 out of every 100,000 adults and accounts for approximately 15% of newly diagnosed adult leukemia cases2. CML is characterized by a non-heritable mutation that leads to a genetic…
Cancer Featured Abstracts

Preformed Cross-Reactive Antibodies to Conserved Epitopes of COVID-19 May Aid in Designing Pan-Coronavirus Vaccines

Christopher Janssen Introduction: COVID-19, the disease caused by SARS-CoV-2, is a global pandemic that has killed at least 5.7 million people and infected 385 million as of February 20221. Despite the successful creation and administration of 11.2 billion vaccines, antibodies generated from these vaccines have demonstrated reduced neutralization of recent…
Featured Abstracts Immunology Microbiology

Parabens as an Avenue for Prophylaxis of Thrombosis in Lemierre’s Syndrome

Mitchell Clark Introduction & Hypothesis: Fusobacterium species, especially F. necrophorum, are the causative pathogens of Lemierre’s Syndrome (LS), which is characterized by disseminated intravascular coagulation and septic emboli.1,2 First-line treatment consists of aggressive antibiotic cocktails; the use of anticoagulants remains controversial, and might increase mortality by creating surgical complications.1,2 How…
Cardiology Featured Abstracts Microbiology

TDP-43 Role in the Pathogenesis of Amyotrophic Lateral Sclerosis and Potential Therapeutic Options

Amir Eldouh Introduction. Amyotrophic Lateral sclerosis is the most common neurodegenerative disorder of motor neurons in adults, with a median survival of 3 to 5 years after appearance of symptoms, and with no current curative treatment options.1 There are over 100 ALS-associated genetic mutation, and several mutations leading to mechanistic…
Featured Abstracts Neuroscience

Emerging Translational Insights from Shigella Evasion of Host Pyroptosis

Jacob Davis Introduction: Shigella is a genus of Gram-negative bacteria that causes dysentery which can be life-threatening in resource-limited settings.1 No vaccines are currently available.1 Recent investigations have demonstrated the importance of pyroptosis—a lytic and inflammatory form of cell death—in defense against Shigella infection. For instance, NAIP-NLRC4 (an inflammasome upstream…
Featured Abstracts Microbiology