The NLRP3 Inflammasome: a Factor in Alzheimer’s Disease Pathogenesis and a Potential Therapeutic Target
Aleksandr Pereverzev Introduction. Alzheimer’s disease (AD) is the most common type of dementia1 and is characterized by amyloid-β (Aβ ) plaques, tau tangles, brain atrophy, and neuroinflammation2. The most accepted model of disease progression is the “amyloid-β cascade hypothesis” which identifies Aβ deposits as the main cause of neurologic dysfunction1.…