Category: Gastroenterology

Host Immunity and Gut Microbiota: A Synergistic Barrier Against C. difficile Colonization

July 22, 2025 Annette Nguyen
Annette Nguyen Background: Clostridioides difficile (C. difficile) is one of the most reported nosocomial pathogens, accounting for 12% of healthcare-associated infections.1 While colonization by C. difficile is common, infection occurs primarily when gut microbiota dysbiosis disrupts colonization resistance, allowing the bacterium to proliferate and produce toxins that damage the intestinal…
Featured Abstracts Gastroenterology Immunology

What’s “Bugging” You? – Investigating the Potential Role of the GI Microbiome in the Association between Appendectomy and Glucose Intolerance

July 25, 2023 Maya Pimentel
Maya Pimentel Background: Approximately 462 million people live with type 2 diabetes mellitus (T2D) worldwide.1 Although, once diagnosed, T2D is a lifelong, often progressive illness that requires regular medical evaluation, it is often a preventable condition. Therefore, attention has switched from a prophylactic response to a preventive approach in T2D…
Engineering Medicine Featured Abstracts Gastroenterology Microbiology

Use of Rifabutin-Based Triple Therapy (RHB-105) to Combat Antibiotic Resistance in Helicobacter pylori Infection Treatment

June 22, 2022 Sayali Shelke
Sayali Shelke Introduction. Helicobacter pylori is a gram-negative bacterial infection that affects 50% of the global human population and is a topic of interest in several fields of medicine due to its severe sequalae, such as peptic ulcer, gastritis, and gastric cancer.2 H. pylori possesses different virulence factors, such as…
Gastroenterology Microbiology

Soy Isoflavones May Help to Reduce Symptomology in Patients with Irritable Bowel Syndrome via Modulation of Estrogen Receptor Beta.

May 31, 2022 Emilia Coffey
Emilia Coffey Introduction. Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder affecting the large intestines.1 It is diagnosed in women more often than men, at a 4:1 ratio. It is estimated to affect between 8-12% of the population.2 IBS is characterized by abdominal pain with altered bowel habits with…
Gastroenterology

Fecal Microbiota Transplant Modulates Clostridium Clusters XIVa, IV, and Caudovirales Bacteriophages to Induce Remission in Ulcerative Colitis Patients

August 16, 2021 Adam Saleh
Adam Saleh Introduction: Ulcerative Colitis (UC) is a chronic idiopathic inflammatory disorder of the colon with continuous inflammation beginning in the rectum and ascending proximally. The disease can present clinically with varying severity of diarrhea and blood in stool, urgency, and tenesmus1. The pathogenesis of UC likely has contributions from…
Gastroenterology Microbiology