Category: Neuroscience

The Role of FKBP5 in the Development of Post-Traumatic Stress Disorder

August 5, 2021 Arthi Tarugu
Arthi Tarugu Introduction. Post-traumatic stress disorder (PTSD) is a psychiatric disorder characterized by abnormal, prolonged stress response to a trauma.1 Susceptibility to development of PTSD following exposure to trauma varies among individuals, suggesting that genetic and environmental factors modulate this stress response.1-5 FK506 Binding Protein 5 (FKBP5) is a major…
Neuroscience Psychiatry

Small Vessel Disease in the Development of White Matter Susceptibility to Necrosis Through Heat Shock Protein 90 Upregulation

August 5, 2021 Armand Tadjali
Armand Tadjali Introduction. Small vessel disease (SVD) is a marked by endothelial dysfunction and blood-brain barrier (BBB) breakdown leading to pathology of dementia, such as white matter damage (demyelination) and amyloid deposits in the brain1,2. However, the mechanisms contributing to these pathologic changes remain unclear. Regulatory molecules that have been…
Neuroscience

The Role Of Trem2 And Its Variant R47H In Alzheimer Disease Progression

August 5, 2021 Will Schmidt
Will Schmidt Introduction: Alzheimer’s disease (AD) is a multifactorial, progressive neurodegenerative disease of aging that accounts for approximately 80% of dementia cases1. Genome wide association studies (GWAS) have identified over 20 mutations that increase risk of AD. Some of these mutations alter inflammatory mechanisms such as phagocytotic clearance of amyloid…
Neuroscience

The Role of Lipid-Droplet-Accumulating Microglia in Driving Neuroinflammation and Alzheimer’s Disease in the Aged Brain

August 4, 2021 Ambeka Rajvanshi
Ambeka Rajvanshi Introduction: Alzheimer’s Disease (AD), the most common cause of dementia, affects ~40 million people worldwide.1 Approximately 90% of AD cases result from mutations in Apolipoprotein (ApoE) E3 and E4, genes associated with proteins involved in lipid transport.1,2 Increased ApoE4 expression is associated with microglial dysfunction, neurodegeneration, and microglial…
Aging Featured Abstracts Inflammation Neuroscience

Microglial Polarization into M1 and M2 Phenotypes: A New Mechanistic Target for Post-Traumatic Epilepsy Treatment

August 3, 2021 Elias Perli
Elias Perli Introduction: Traumatic Brain Injury (TBI) is a change in normal brain function caused by an external insult. More than 3 million people in the United States suffer a TBI annually, accounting for around 300,000 hospitalizations and 50,000 fatalities per year.1,4 One notable sequela of TBI is Posttraumatic Epilepsy…
Immunology Neuroscience Psychiatry

Fibrillar alpha-Synuclein Can Induce NLRP3-Inflammasome Activation in Parkinson Disease (PD)

August 3, 2021 Shivam Patel
Shivam Patel Introduction. Parkinson disease (PD) is the second most common neurodegenerative disease, causing dopaminergic neuronal cell loss in the substantia nigra (SN).1,2,3 PD affects approximately 1-2% of the total population over the age of 60.3 Pathologically, PD involves misfolded aggregates of a-synuclein known as Lewy bodies.1 The decreased dopamine…
Inflammation Neuroscience Stem Cells