Author: Michael Neff

Adjunctive Treatment of Neurosteroids Sequesters Drug-Resistant Behavioral Seizures in Children with CDKL5 Deficiency Disorder

September 26, 2024 Michael Neff
Michael Neff Background: Cyclin-dependent like kinase 5 (CDKL5) Deficiency Disorder is an X-linked mutation that leads to severe developmental delays, spontaneous seizures, and early death in infants.6,7,8 CDKL5 is a serine threonine kinase that is a key regulator of early neuronal development that controls the aggregation of glutamatergic receptors, GABA-A…
Featured Abstracts Psychiatry

Mast Cell Inhibitors as a Potential Target for Mitigation of Food Allergies

June 28, 2024 Shrey Patel
Shrey Patel Background: There are approximately 33 million Americans currently living with food allergies (FA), defined by their characteristic exaggerated immune responses to certain food allergens1.These unwanted allergic reactions may lead to severe life-threatening medical emergencies such as anaphylactic shock2. To prevent the immune response from progressing further, therapies such…
Engineering Medicine Featured Abstracts Immunology

Capsular Contracture: An Immunological Balancing Act

June 28, 2024 Afridi Abdullah
Afridi Abdullah Background: Capsular contracture (CC) is a common complication following breast implant surgery, marked by the abnormal thickening of fibrotic tissue around the implant. Specifically, there is an incidence of 10.6% across all implants.1 This condition leads to aesthetic changes, discomfort, and pain, impacting patient satisfaction and requiring surgical…
Engineering Medicine Featured Abstracts Fibrosis Immunology

Food for a Better Mood: Diet as a Modulator of the Gut Microbiome for the Treatment of Depression

June 28, 2024 Raiyan Talukder
Raiyan Talukder Background: Depression is one of the most common mood disorders in the world, characterized by at least 2 weeks of depressed mood, anhedonia, loss of interest, and other symptoms.1 Unfortunately, depression is a growing issue, affecting over 280 million people worldwide with some communities observing a large uptick…
Engineering Medicine Featured Abstracts Microbiology Psychiatry

Examining Helicobacter Pylori Pathogenesis and Motility Mechanisms

June 28, 2024 Anita Sumali
Anita Sumali Background: Helicobacter pylori (H. pylori) is one of the most prevalent human pathogens worldwide, infecting approximately half of the global population1. Its association with numerous gastrointestinal disorders, including gastritis, peptic ulcers, and gastric cancer highlights the urgent need for a thorough understanding of its pathogenesis mechanisms2. While extensive…
Engineering Medicine Featured Abstracts Microbiology

Bacteriophage Therapy as a Means of Resolving Biofilm Formation On Vascular Prostheses

June 28, 2024 Veronica Stuckey
Veronica Stuckey Background:  Vascular graft infections (VGIs) present an uncommon (1-3%) but potentially deadly (mortality 20-30%) post-surgical adverse effect. VGIs are biofilm associated infections resistant to antibiotic treatment due to difficulty penetrating the biofilm microenvironment[1]. Patients within the first 4 months post-operatively are at the highest risk of infections from…
Cardiology Engineering Medicine Featured Abstracts Microbiology