Author: Solyman Hatami

The Role of Organ-on-a-Chip Devices in Alzheimer’s Disease Drug Discovery and Disease Modeling

August 18, 2021 Solyman Hatami
Solyman Hatami Introduction: Alzheimer’s disease (AD), the leading cause of dementia worldwide, is an irreversible neurodegenerative disease characterized by memory loss and executive dysfunction.1  It is characterized by intracellular neurofibrillary tangles and extracellular amyloid beta (Aβ) plaques through improper cleavage of amyloid precursor protein by β-secretases. Aβ aggregation is known…
Engineering Medicine Neuroscience

The Role of Polycystin 1 and Polycystin 2 (PC1/PC2) in Calcium Intake and Pathogenesis of Autosomal Dominant Kidney Disease

August 18, 2021 Tarek Dawamne
Tarek Dawamne Introduction. Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common potentially lethal single gene disorder. ADPKD is often associated with renal cysts that cause increased kidney malfunction such as hematuria, flank pain, kidney stones, carcinoma, in addition to other cardiovascular abnormalities1.  Methods. Many sources were reviewed to…
Featured Abstracts Renal Genitourinary

Optimization of Targeted, Nanoparticle-Mediated Therapy for Enhanced Triple Negative Breast Cancer (TNBC) Treatment

August 17, 2021 Niharika Choudhury
Niharika Choudhury Introduction. Triple Negative Breast Cancer (TNBC) comprises 15-20% of all breast cancers and is considered the most aggressive phenotype.1,2 It is diagnosis of exclusion, characterized by the loss of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2/neu).1,2 This genomic instability leads to…
Cancer Engineering Medicine

Utilizing Vessel Visualization through Fluorescent Tracers, such as Indocyanine Green Fluorescence, to Evaluate Integrity of Vasculature Intraoperatively and Reduce Complication Rates

August 17, 2021 Robert Loving
Robert Loving Introduction. During surgical operations, greater understanding of a patient’s specific blood flow to an area and additional information allowing for a more complete understanding of the areas vasculature allows surgeons so make the most informed decision and produce better outcomes for their patients1,2. Most methods of vessel visualization…
Cardiology Engineering Medicine

COVID-19 Cytokine Storm Causes Myocarditis Characterized by Reduced Cardiac Function, Fibrosis, and Increased Mortality

August 16, 2021 Brianna Cathey
Brianna Cathey Introduction. Myocarditis is the most frequent manifestation of COVID-19 cardiac involvement, causing up to 7% of COVID related deaths.1,2 Cardiac injury occurs in approximately 12% of patients and has shown a 51% mortality rate in hospitalized COVID-19 patients.3 While it has been established that COVID-19 particles enter the…
Cardiology Microbiology

An Application of Lipid Nanoparticles in Delivering mRNA Vaccine for Cancer Immunotherapy

August 16, 2021 Hengji Zhang
Hengji Zhang Introduction. Melanoma occurs when melanocytes in the basal layer of epidermis become cancerous. Surgical resection of the tumor and surrounding tissue is the primary treatment for localized melanoma. Before the development of targeted therapies and immunotherapies, chemotherapy was often used for patients with metastatic cancer. The BRAF inhibitors,…
Cancer Engineering Medicine