Author: Charmi Mehta

DNMT-Mediated Pathways in the Progression, Immune Regulation, and Drug Resistance of Multiple Myeloma Indicate the Potential of DNA Methylation Inhibitors

August 2, 2021 Lynnsey McLain
Lynnsey McLain  Introduction. Multiple myeloma is a malignancy of plasma cells in the bone marrow, resulting in the excessive production of non-functional immunoglobulins.1 The incidence of multiple myeloma in the US is approximately 4 per 100,000 people, which accounts for more than 10% of all hematological malignancies and 1% of…
Cancer Immunology

Mesenchymal Stem Cell Exosomes Target VEGF and BMP-2 Expression and Hippo Signaling Pathway to Treat Osteonecrosis of the Femoral Head

August 2, 2021 Morgan McAdams
Morgan McAdams Introduction. Osteonecrosis of the femoral head is a bone lesion characterized by disruption of circulation, which leads to a decrease in bone growth and increased fat deposition.8 A lack of effective noninvasive treatments has led to the exploration of mesenchymal stem cell exosomes as a potential therapeutic tool.7-8…
Orthopedics Stem Cells

The Role of the PI3k/Akt/mTOR Signaling Pathway in Mediating Poly(ADP-Ribose) Polymerase Inhibitor (PARP1) Resistance in BRCA-Deficient Ovarian Cancer Patients

August 2, 2021 Scott Mayo
Scott Mayo  Introduction. Platinum-based chemotherapy resistance has been a major challenge in BRCA deficient ovarian cancer patients.1,2,3,4,5 BRCA deficient cancer cells have a decreased ability to repair double stranded DNA breaks. This single-hit mutation is advantageous to the cancer cells, allowing for mutation to be sustained.5 Studies have shown that…
Cancer Featured Abstracts

The Relationship Between Regulatory T Cells (CD4+/CD25/ FOXP3) and Abnormal Lymphangiogenesis in the Pathophysiology of Preeclampsia

August 2, 2021 Ana Mathew
Ana Mathew Introduction: Preeclampsia (PE) is the leading hypertensive disorder of pregnancy affecting approximately 5-10% of pregnant mothers. 1-3 Despite its prevalence, the exact mechanism causing PE remains elusive.3 In previous experimental models of PE, there has been evidence of deficiencies in regulatory T cell (Treg) counts leading to excessive…
Immunology Reproduction

The Immunomodulatory Function of MSC Derived Exosomes on M2 Macrophage Polarization in Osteoarthritis via Delivery of miRNA-223

August 2, 2021 Hamza Malick
Hamza Malick Introduction: Osteoarthritis (OA) is an autoimmune disorder characterized by the degradation of cartilage and chronic inflammation at the synovium. It is considered to be one of the most prevalent causes of morbidity and disability in individuals over 40, with treatment currently limited to NSAID’s, steroids, and other symptomatic…
Immunology Orthopedics

Alpha-Synuclein Propagates in a Prion-Like Fashion from the Gut to the Brain Inducing Parkinson’s Disease Pathology

August 2, 2021 Jessica Madry
Jessica Madry Introduction. On the global scale there is a prevalence of 100-300/100,000 people with Parkinson’s Disease (PD) and it is expected to double by 2030 due to the progressive aging of the world population1. Parkinson’s Disease is a multi-systemic neurodegenerative disease characterized by the degeneration of dopaminergic neurons in…
Neuroscience

Downregulation of the Melatonin Receptor MT1 on the Neuronal Outer Mitochondrial Membrane (OMM) Is A Key Determinant of the Initial Onset and Pathogenesis of Huntington’s Disease

August 2, 2021 Kendahl Lyle
Kendahl Lyle Introduction. Huntington’s disease is an autosomal dominant disease due to a CAG trinucleotide repeat on chromosome 4 and the greater number of repeats corresponds to an earlier onset of symptoms.1 Huntington’s disease has a prevalence of 10.6-13.7 per 100,000 in western populations, and females are shown to have…
Neuroscience

Disruption of TET2 Supports CAR-T Anti-tumor Response in CLL Treatment

August 2, 2021 Mailin Li
Mailin Li Introduction. Chronic Lymphocytic Leukemia (CLL) is a cancer of mature B-cells and is the predominant leukemia affecting Western countries.1 Chimeric antigen receptor T-cell (CAR-T) therapy is a promising alternative treatment for many B-cell malignancies including CLL, especially for patients refractory or relapsed to standard treatments.1 In CAR-T therapy,…
Cancer