Category: Inflammation

Fibrillar alpha-Synuclein Can Induce NLRP3-Inflammasome Activation in Parkinson Disease (PD)

August 3, 2021 Shivam Patel
Shivam Patel Introduction. Parkinson disease (PD) is the second most common neurodegenerative disease, causing dopaminergic neuronal cell loss in the substantia nigra (SN).1,2,3 PD affects approximately 1-2% of the total population over the age of 60.3 Pathologically, PD involves misfolded aggregates of a-synuclein known as Lewy bodies.1 The decreased dopamine…
Inflammation Neuroscience Stem Cells

Role of Mesenchymal Stem Cells in Treating Rheumatoid Arthritis By Altering Th17/Treg Ratio

August 3, 2021 Amisha Patel
Amisha Patel Introduction: Rheumatoid Arthritis (RA) is a chronic inflammatory disease in the joints that negatively impacts bone constitution, mobility, and overall quality of life.1 The presence of helper T cells (Th17) cells, and downregulation of regulatory T cells (Treg) cells, in inflammation sites, is a prominent feature of Rheumatoid…
Immunology Inflammation Stem Cells

Helicobacter pylori Exosomes Induced Upregulation of NLRP12 Reduces NF- κB Inflammation in Ulcerative Colitis

July 27, 2021 Aidan Filley
Aidan Filley Introduction: Ulcerative colitis (UC), a disease characterized by intestinal inflammation with complex etiology has hypothesized genetic predispositions, environmental triggers and microbiome dysbiosis.1-3 Helicobacter pylori (H. pylori), a gram-negative spiral pathogenic bacteria, lives in the stomach of @50% of the human population and causes atrophic gastritis in 10-20% and…
Inflammation Microbiology

The Role and Effects of Inhibiting LOXL2 in Liver Fibrosis

July 26, 2021 Luke Eldore
Luke Eldore Introduction: Liver fibrosis is a common pathological process seen in numerous liver disease, such as Non-Alcoholic Fatty Liver Disease (NAFLD).1 NAFLD has nearly a 25% prevalence world-wide, and mild fibrosis is seen in this stage of disease. Fibrosis becomes more prevalent as the liver progresses from NAFLD into…
Inflammation

Novel Treatment of Myasthenia Gravis through Suppression of the Complement Cascade

July 26, 2021 Emily Danielson
Emily Danielson Introduction. Myasthenia Gravis (MG) is an autoimmune disease characterized by dysfunction of the neuromuscular junction.1 The basic abnormality in MG is a reduction in the acetylcholine receptors at neuromuscular junctions due to the effects of autoantibodies.1 The strongest evidence for complement dependent cytotoxicity in MG comes from the…
Inflammation Neuroscience

Role of Matrix Metalloproteases (MMP) Inhibitors in Decreasing Permeability of the Blood-Brain Barrier and Modulation of Inflammatory Response during Ischemic Stroke

August 11, 2020 Ashmi Patel
Ashmi Patel Introduction. Stroke outco me is dependent on several factors including the permeability of the blood-brain barrier (BBB) by matrix metalloproteases (MMPs).2  In ischemia, MMP-2 and MMP-9 degrade claudin-5, which facilitates the increased permeability of the BBB and decrease in tight junction proteins (TJPs).2  MMP-9 cleaves ZO-1 and degrades…
Cardiology Inflammation

The Role of T-Regulatory Cells on the Development of Systemic Lupus Erythematosus

August 11, 2020 Peter Lin
Peter Lin Introduction. Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease in which circulating autoantibodies and immune complexes deposit, activating the compliment system and causing local inflammation and tissue destruction throughout the body1-2. SLE usually starts in late childhood to young adulthood, predominantly affecting females in reproductive years3. Dysfunction…
Immunology Inflammation