Category: Endocrinology

Analyzing Androgen Receptor Amplification and Mutations in Castration Resistant Prostate Cancer Using Liquid Biopsy

June 12, 2024 Belle Skaggs
Belle Skaggs Background:  Prostate cancer is the second most common cancer and second leading cause of cancer related mortality in American men1. One therapy commonly used to treat prostate cancer is androgen deprivation therapy (ADT), which creates a state of androgen deprivation in cancer cells that induces apoptosis1. Unfortunately, after…
Cancer Endocrinology

Healing Potential: Enhancing Angiogenesis with induced Mesenchymal Stem Cell release of HIF1α/VEGF in Diabetic Foot Ulcer Therapy

June 5, 2024 Vivanna Nguyen
Vivanna Nguyen  Background: Currently, approximately 11.6% of Americans have been diagnosed with diabetes and this number continues to rise at an alarming rate.1 Diabetic foot ulcers (DFU) are a common complication of DM that are difficult to treat due to impaired wound healing as a result of hyperglycemia, peripheral arterial…
Diabetes Endocrinology

Exercise Improves Depression Through Interleukin-6

June 5, 2024 Hobad Huy Nguyen
Hobad Huy Nguyen Background: Depression is a mental health disorder that affects 300 million people worldwide1 and is characterized by persistent impaired motivation, decreased mood, and in severe cases suicidality.2 According to the Diagnostic and Statistical Manual Version 5, Major Depressive Disorder (MDD) lasts for at least two weeks and…
Endocrinology Psychiatry

Role of Estrogen in Modulating Multiple Sclerosis Progression

May 30, 2024 Lauren S. Franklin
Lauren S. Franklin Background: Multiple sclerosis (MS) is an autoimmune neurological disorder characterized by demyelination of neurons in the central nervous system and affects an estimated 900,000 individuals in the United States.1 A notable risk factor for MS is infection with Epstein-Barr virus (EBV), which induces EBV-activated T-cells that cross-react…
Endocrinology Featured Abstracts Neuroscience

The Therapeutic Impact of Exercise-Induced Myokine Secretion in Reducing Oxidative Stress (OS) and Minimizing Diagnostic Symptoms of Polycystic Ovarian Syndrome (PCOS)

May 29, 2024 Courtney Coe
Courtney Coe Background: Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine disorders in reproductive-aged women. An imbalance in hypothalamic-pituitary-ovarian axis signaling leads to symptoms such as excess androgens and ovarian dysfunction. Insulin resistance and compensatory hyperinsulinism are major factors affecting those with PCOS.1 Current guidelines for diagnosis…
Endocrinology Featured Abstracts Reproduction

GLP-1R Agonists in the Treatment of Diabetes Mellitus: Reducing Serious Comorbidities

July 25, 2023 W. Marshall Fettig
W. Marshall Fettig Background: Type 2 Diabetes Mellitus (T2DM) is a major health problem worldwide, characterized by persistent hyperglycemia, and associated with both long and short-term complications. T2DM affects approximately 374 million adults aged 20-79 worldwide,1 and its impact on the US economy was estimated at $327 billion in 2017.2…
Endocrinology Engineering Medicine

Triple Combination Therapy of CDK4/6 Inhibitors, Endocrine Therapy, and mTOR/PI3K Inhibitors to Treat Hormone Receptor-Positive Human Epidermal Growth Factor Receptor-2 Negative Breast Cancer with Acquired Resistance

June 22, 2023 Rebecca Waugh
Rebecca Waugh Background: In America breast cancer is the most frequently diagnosed malignancy in women2,5. Hormone receptor-positive human epidermal growth factor receptor-2 negative (HR+/HER2-) tumors categorize 65-70% of all cases and has one of the lowest survival rates1,2. Recent meta-analysis incorporate modulation CDK 4/6 inhibitors (CDKi) with endocrine therapy as…
Cancer Endocrinology Featured Abstracts

The Potential Use of CDK7 Inhibitors to Treat Metastatic Castration-Resistant Prostate Cancer via Reduction in MED1 Phosphorylation and Androgen Receptor Signaling.

June 21, 2023 Michael Hembrough
Michael Hembrough Background: Prostate cancer (PC) is the most common malignancy in men. 1,2 PC begins with mutations in prostatic ductal epithelial cells, which produce androgen receptor (AR), a transcriptional regulator for genes controlling cell homeostasis. 1 These mutations increase AR signaling, driving tumorigenesis and metastasis. 2 Eventual progression to…
Cancer Endocrinology Featured Abstracts