Month: May 2022

Mesenchymal Stem Cell Therapy Induces FLT3L and CD1c+ Dendritic Cells That Are Deficient in Systemic Lupus Erythematous

May 31, 2022 Amanda Duong
Amanda Duong Introduction: Systemic Lupus Erythematous (SLE) is characterized by exaggerated B and T cell responses and loss of immune tolerance against self-antigens.1 SLE is also characterized by remission and relapse phases rather than progressive like rheumatoid arthritis. It is the direct immune mediated tissue damage that leads to the…
Immunology

Psilocybin Causes a Long Term Change in 5-HT2A Receptors that Increased Neuroplasticity in Patients with Depression

May 31, 2022 Justin Dugie
Justin Dugie Introduction: MDD(Major Depressive Disorder) is the largest global burden on disease with a 15% lifetime prevalence.7 MDD is associated with increased resting FC(Functional Connectivity) in the medial frontal lobe, temporal lobe and basal ganglia to other regions, and decreased cerebellum FC.7 FC is used as one of the…
Neuroscience Psychiatry

Mechanical Vibration Induces Differentiation of Mesenchymal Stem Cells to Osteoblasts at the Expense of Adipocyte Differentiation through Activation of Wnt Pathway and Inhibition of PPARgamma Nuclear Hormone Receptor in Osteoporotic Bone

May 31, 2022 Dakota Doucet
Dakota Doucet Introduction. Osteoporosis (OP) in post-menopausal women causes abnormally low bone mineral density, bone fragility, and high bone marrow adipocyte content. With 54 million currently afflicted in the United States and another 120 million predicted to suffer from OP by 2050 in China1, substantial efforts have been directed towards…
Orthopedics Stem Cells

Emerging Translational Insights from Shigella Evasion of Host Pyroptosis

May 31, 2022 Jacob Davis
Jacob Davis Introduction: Shigella is a genus of Gram-negative bacteria that causes dysentery which can be life-threatening in resource-limited settings.1 No vaccines are currently available.1 Recent investigations have demonstrated the importance of pyroptosis—a lytic and inflammatory form of cell death—in defense against Shigella infection. For instance, NAIP-NLRC4 (an inflammasome upstream…
Featured Abstracts Microbiology

Noradrenergic Hyperactivity and Resulting Denervation Explains Key Aspects of Non-Alcoholic Fatty Liver Disease (NAFLD) Pathology

May 31, 2022 Glori Das
Glori Das Introduction: An estimated 25% of the global population suffers from Non-Alcoholic Fatty Liver Disease (NAFLD)1. NAFLD is a progressive condition characterized by hepatocyte lipid accumulation (HLA) and fibrosis in its more advanced stages. Multiple pathways controlled by noradrenergic (NAergic) signaling have been implicated in NAFLD pathogenesis2,3,4. The goal…
Hepatology

TRPV4 Calcium Ion Channels Act as Potential Target for Preventing Myocardial Fibrosis

May 31, 2022 Harshith Dasara
Harshith Dasara Introduction. Myocardial fibrosis is the abnormal expansion of myocardium due to excessive deposition of extracellular matrix via activation of fibroblasts.1 Despite fibrosis having a critical role of preserving structural integrity following myocardial infarction (MI), increased future susceptibility for heart failure is the result.2,3 Every year, over 700,000 Americans…
Cardiology

Elucidating the Mechanism of Endothelium-Dependent Coronary Microvascular Dysfunction Linked to Diastolic Dysfunction with Heart Failure

May 31, 2022 Vy Dang
Vy Dang Introduction. Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for 50% of all HF cases, affecting ~2.5 million patients in 2019. Individuals with HFpEF present typical signs and symptoms of HF such as shortness of breath, edema, fatigue, left ventricle (LV) hypertrophy, and diastolic dysfunction.2 LV hypertrophy…
Cardiology