Month: May 2024

Upregulation of KCC2 Expression Leads to Decreased Spasticity Symptoms Post Spinal Cord Injury

May 31, 2024 Diego Miranda
Diego Miranda Background: Spasticity, a product of spinal cord injury (SCI), is characterized by hyperreflexia, muscle spasms, co-contraction of antagonist muscles and clonus.1 After an SCI, there is a decrease in the expression of the potassium-chloride co-transporter, also known as KCC2, leading to an excitatory/inhibitory imbalance and self-sustained activity in…
Featured Abstracts Neuroscience

Exploring the Pro-Inflammatory Cascade Associated with Psoriasis in the Down Syndrome Population

May 31, 2024 Abigail Medford
Abigail Medford Background: Individuals with Down syndrome (DS) have T cell dysregulation with abnormally elevated baseline pro-inflammatory and multiple overly activated immune cell types. Thus, they are much more likely to develop autoimmune inflammatory conditions.1 Psoriasis is a chronic autoimmune skin disorder marked by abnormal skin cell proliferation that frequently…
Featured Abstracts Immunology Inflammation

The Use of Music Therapy in Children with ASD and its benefits in Social Communication and Language Deficits

May 31, 2024 Claire Heigl Maza
Claire Heigl Maza Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by a lack of social communication and use of restricted, repetitive behaviors. 2 Children with ASD often suffer from speech and language delays including difficulty in recognizing emotions from verbal stimuli. While treatments and interventions used in…
Featured Abstracts Psychiatry

Role of Ephrin B2 (EphB2) and Postsynaptic Density Protein 95 (PSD-95) in Internalization and Stabilization of N-methyl-D-aspartate (NMDA) Receptors in NMDAR Autoimmune Encephalitis

May 31, 2024 Alexis Magre
Alexis Magre Background: Anti-N-Methyl-D-Aspartate receptor (anti-NMDAR) encephalitis is characterized by an acute decline in cognitive function, psychiatric symptoms, seizures, and movement disorders.1-3  The main pathologic mechanism of anti-NMDAR encephalitis is internalization of NMDARs after autoantibodies bind to the GluN1 subunit which causes subsequent neuronal hypoactivity.2,3 There are few approved therapies…
Inflammation

Reducing Neurodegeneration in Alzheimer’s Disease through miR-29c-3p, Carried by Mesenchymal Stem Cell-Derived Extracellular Vesicles

May 31, 2024 Lucas Lott
Lucas Lott Background: As life expectancy continues to rise globally, the increase in population aging has reflected a similar increase in neurological diseases (NDs), such as Alzheimer’s disease (AD)1. AD is categorized as a decline in memory, cognition, awareness, and motor functionality as a result of the accumulation of amyloid-beta…
Featured Abstracts Neuroscience

The Impact of Selective Serotonin Reuptake Inhibitor Use During Pregnancy on Embryonic Neurodevelopment

May 31, 2024 Daniela Lopez
Daniela Lopez Background: Perinatal depression is a mood disorder that affects about 7-20% of women during pregnancy.1 To be diagnosed, a woman must experience a major depressive episode during pregnancy according to the DSM-5.2 Currently, first line treatment consists of Selective Serotonin Reuptake Inhibitors (SSRI), but other treatment options include…
Featured Abstracts Reproduction

Anti-Ro52 Autoantibodies’ Role in Autoimmune Disorders, Inflammatory Myopathies, and Interstitial Lung Disease

May 31, 2024 Ashleigh Little
Ashleigh Little Background: Autoimmune connective tissue diseases (CTDs) are disorders characterized by the immune system attacking the body’s tissues. These diseases can affect various organs and systems, leading to various clinical manifestations. This research specifically analyzed mixed connective tissue disease (MCTD), polymyositis/dermatomyositis (PM/DM), and systemic sclerosis (SSc). Objectives: This review…
Featured Abstracts Immunology Inflammation Respiratory