Category: Stem Cells

Mesenchymal Stem Cells in the Treatment of Type I Diabetes Mellitus

July 23, 2018 William Shank
William Shank Introduction. Type I diabetes mellitus (T1D) is a chronic disease characterized by autoimmune destruction of pancreatic β-cells leading to chronic insufficient insulin production. Lymphocytic infiltration and destruction of these cells, along with circulating islet cell antibodies and anti-insulin antibodies are seen in T1D patients1,2. Treatment of T1D currently…
Endocrinology Immunology Stem Cells

Expression of Pdx-1 on Stem Cells Increases Pancreatic Beta Cell Regeneration in Treatment of Diabetes Mellitus

July 23, 2018 Radhika Shah
Radhika Shah Introduction. Diabetes mellitus is a chronic disease in which the level of glucose in the blood cannot be maintained. Type I diabetes manifests as an autoimmune disorder, in which the patient’s immune system attacks the insulin-producing beta cells of the pancreas. When these cells become deficient, insulin production…
Endocrinology Immunology Stem Cells

Evolving Utilization of Mesenchymal Stem Cells and Delivery Scaffolds in Osteoarthritis

July 23, 2018 John Schmidt
John Schmidt Introduction. Osteoarthritis (OA) is a chronic degenerative joint disease that causes pain, decreased range of motion, osteophyte formation, and aberrant bone remodeling in over 27 million adults in the United States alone1,2. Numerous interacting growth factors and inflammatory cytokines modulate the various pathways that lead to chondrocyte hypertrophy…
Immunology Orthopedics Stem Cells

Targeting Myocardiocyte Stem Cells For Tissue Mediation Following Myocardial Infarction

July 23, 2018 David Chapman
David Chapman Introduction: In the US, cardiovascular disease and myocardial infarctions (MI) are leading causes of morbidity and mortality. Approximately 790,0001 individuals in the US experience an MI annually, with over 100,000 of them resulting in death. Unfortunately, an MI is associated with lasting negative health implications, including irreversibly damaged…
Cardiology Stem Cells

Immunomodulatory Effects of Mesenchymal Stem Cells on the Aberrant T-cell Response in Crohn’s Disease

July 20, 2018 Samuel Lyons
Samuel Lyons Introduction: Crohn’s disease (CD) is a chronic inflammatory disease of the bowel resulting from dysregulated immune responses toward microbial antigens like muramyl-dipeptide (MDP), a frequent member of healthy intestinal flora1. Studies have demonstrated a connection between this immune response and unbalanced populations of Treg, Th1, and Th17 cells…
Immunology Inflammation Stem Cells

hUBC-MSC Treatment in Rheumatoid Arthrits

July 11, 2018 Logan DuBose
Logan DuBose Introduction: Rheumatoid Arthritis is an inflammatory disease characterized by the swelling of joints and destruction of cartilage, synovium, and bone. Current treatments include medications that inhibit inflammatory cytokines such as TNFα, however 50% of patients do not respond adequately to the treatment1. The need for other therapeutic drug…
Inflammation Stem Cells