Author: July Jost

Mesenchymal Stem Cell Homing through the SDF-1/CXCR4 Axis and its Potential in Primary Osteoporosis Therapeutics

July 30, 2021 July Jost
July Jost Introduction. Primary Osteoporosis (OP) is the most common bone disease worldwide and is characterized by an imbalance in bone homeostasis with a bone mineral density (BMD) 2.5 standard deviations below average1,2. This increases the risk for fracture development1,2. Declining levels of sex-steroids associated with menopause in women and…
Orthopedics Stem Cells

Promoting Brain Repair After Traumatic Brain Injury through IL-6 Trans-Signaling Dependent Microglial Repopulation

July 30, 2021 Marita John
Marita John  Introduction: Traumatic brain injury (TBI) is one of the major causes of morbidity and mortality worldwide.1 The hallmarks of TBI include cognitive dysfunction and activated microglia, but it is unclear whether activated microglia are harmful or beneficial. Recent studies have investigated whether manipulating the activation of microglia or…
Neuroscience

The Downstream Effects of Mycobacterium Tuberculosis Binding of TLR2 and its Role in Potential Therapeutics

July 30, 2021 Cade Janke
Cade Janke Introduction: Activation of the innate immune response is key in fighting off Mycobacterium tuberculosis (Mtb).[1][2] However, Mtb alters the PAMP-TLR2 relationship to evade this response. Alterations include modified bacterial wall components that are recognized by TLR2.[2] This results in decreased production of proinflammatory cytokines which are necessary to…
Immunology Microbiology

The Role of Mesenchymal Stem Cell-Derived Extracellular Vesicles (MSC-EVs) in Promoting M2 Macrophage Polarization in Severe Cutaneous Burn Wounds Following MSC Treatment

July 29, 2021 Ian T. Bui
Ian T. Bui Introduction. Severe cutaneous burn wound is classified as a third- or higher-degree full thickness burn that involves destruction of epidermis and dermis1. Macrophages influence all steps in wound healing through their phenotypic polarization: pro-inflammatory M1 phenotype and anti-inflammatory M2 phenotype2,3. Traditional treatments such as Early Excision and…
Stem Cells Wound Healing

Inhibition of Wnt/beta-catenin Signaling Induces Greater Susceptibility to Therapies in Castration Resistant Prostate Cancer

July 28, 2021 Alex Pham
Alex Pham Introduction: Castration resistant prostate cancer is a progression of prostate cancer that results when cancer cells develop mechanisms that enable them to stimulate their own androgen receptors.1 It is estimated about 10-20% of prostate cancers will progress to CRPC and the estimated mean survival of CRPC patients is…
Cancer Featured Abstracts