Author: Madeline Franke

New Advances in Utilizing Microparticle Drug Delivery Systems for Targeted, Intra-articular Drug Therapy in Osteoarthritis

August 10, 2021 Madeline Franke
Madeline Franke Introduction: Osteoarthritis (OA) is a debilitating, degenerative joint disease that affects approximately 250 million people worldside1. OA is a leading cause of physical disability and its risk increases with factors such as age, obesity, and joint injury1,2. OA involves a mismatch between the anabolism and catabolism of cartilage…
Engineering Medicine Inflammation Orthopedics

The Effects of Oxidative Stress on Endometriosis

August 10, 2021 Rachel Stading
Rachel Stading Introduction. Endometriosis is a chronic disease in which uterine tissue is implanted outside of the uterus1. This disease affects one in every 10 women2. The risk of endometriosis increases with increasing ovulatory cycles; therefore, women with less pregnancies or irregular menstrual cycles may be at higher risk of…
Gynecology

Gut Dysbiosis in Type 1 Diabetes: Islet Cell Cytokine Response to Co-Culture with Bacteroides Dorei

August 10, 2021 Tanner Walker
Tanner Walker Introduction. Type 1 diabetes (T1D) is a chronic autoimmune disease, affecting 1.6 million Americans, that destroys β cells in the pancreas resulting in chronic hyperglycemia if left untreated with daily exogenous insulin 1 – 4. With 64,000 Americans being newly diagnosed each year, a juvenile onset, and a…
Endocrinology Featured Abstracts Microbiology

Therapeutic Treatments of Ischemic Strokes

August 10, 2021 Alwin Mathew
Alwin Mathew Introduction. A stroke is a neurological deficit caused by a lack of blood flow to an area of the brain. It is the second leading cause of death and the third leading cause of disability in adults.8 Neuroimaging is key to differentiate between ischemic and hemorrhagic strokes.4 Ischemic…
Cardiology

The Use of Bioprinted Skin Grafts for Burn Wound Healing

August 6, 2021 Kavya Yeruva 
Kavya Yeruva  Introduction: Burns are one of the most common types of trauma, resulting in damage to the epidermis, dermis, and occasionally underlying tissue. The resulting pro-inflammatory response is initiated by vasodilation of nearby blood vessels and diapedesis of various cells into the injured area.1,2,3 Macrophages then release cytokines like…
Wound Healing

The Role of H19 and Other Long Non-Coding RNAs in Cardiac Hypertrophy: Novel Treatment and Prevention Strategies for Hypertrophic Cardiomyopathy

August 6, 2021 Matthew Wooten
Matthew Wooten Purpose. Hypertrophic Cardiomyopathy (HCM) is characterized by abnormal hypertrophy of the heart, often with preference of the interventricular septum.1, 2 It’s prevalence is as high as 1 in 500 adults, and is the most common cause of sudden cardiac death in young athletes.1 It is typically caused by…
Cardiology

The Role of DNA Methylation as an Epigenetic Mechanism of the Neuroadaptations Associated with Cocaine Use Disorder

August 6, 2021 Rachael Wong
Rachael Wong Introduction. Cocaine use disorder is 79% heritable, and 2 million Americans use cocaine monthly with over 850,000 of them meeting the DSM-V criteria for cocaine dependence.5,9 While identification of specific genetic factors and pharmacological treatment has remained elusive, promising results are arising from the study of epigenetic modifications…
Featured Abstracts Neuroscience Psychiatry

The Developmental and Neurotoxic Effects of Propofol

August 6, 2021 Alyson Win
Alyson Win Introduction: Propofol is one of the most widely used intravenous anesthetics in the United States. While it is considered to be safe in a healthy, developed brain, there has been growing evidence that propofol is neurotoxic in neonatal animals. The general mechanism of propofol toxicity seems to be…
Development

Mechanisms of Castration Resistant Prostate Cancer Progression: Intratumoral Androgen Synthesis and Overactivity of the Androgen Receptor

August 6, 2021 Gregory Wilson
Gregory Wilson Introduction: Prostate cancer is the second most diagnosed cancer among males and the sixth most common cause of death of men in the world2. While first line therapies, including androgen deprivation therapy, are effective treatments for most patients, some suffer a progression of the disease to castration resistant…
Cancer