Targeted Inhibition of the Piezo1/YAP Mechanotransduction Axis Reverses the Pro-Fibrotic Phenotype in Keloids

Aakaash Duggal Background: Keloids are benign, dermal fibroproliferative growths characterized by excessive collagen accumulation that actively invades beyond original wound margins.ยน They disproportionately affect individuals with darker skin pigmentation (Fitzpatrick skin types IV-VI) and preferentially develop in anatomical areas subjected to high mechanical skin tension, such as the chest and…
Dermatology