Category: Inflammation

Targeting Serum Cytokines as Prognostic Biomarkers for COVID-19 Biosensors

June 28, 2022 Shourya Kumar
Shourya Kumar and Limei Tian, PhD Introduction: Coronaviruses are enveloped RNA viruses in humans and animals that can cause acute and chronic diseases1. In patients with a weak immune system or other (unknown) pre-existing conditions, an uncontrolled inflammatory response linked to a cytokine storm has been associated with severe pulmonary…
Engineering Medicine Immunology Inflammation Microbiology

Cellular Senescence Is Associated with Phenotypic Changes that Promote Inflammation and Aging

June 27, 2022 Emily Lo
Emily Lo Introduction: Cellular senescence is a cell stage associated with DNA damage in which a cell can no longer replicate and gains resistance to apoptosis1. Senescent cells secrete an array of inflammatory cytokines and chemokines, including TNF-alpha, IL-6, and IL-81. Accumulation of senescent cells and their associated inflammation is…
Aging Engineering Medicine Featured Abstracts Inflammation

Elevated Proinflammatory Cytokines in Patients with Depression

June 24, 2022 Elizabeth Bixler
Elizabeth Bixler Introduction: Major Depressive Disorder (depression) is a mood disorder thought to be driven by neurotransmitter imbalance. It is the leading cause of disability worldwide1, and in any given year, 17.3 million Americans suffer from depression2. Many groups have studied the link between elevated proinflammatory cytokines and depression and…
Engineering Medicine Inflammation Psychiatry

The Role of Biogenetics for PRP Injections in Lateral Epicondylitis

June 24, 2022 Krishna Anand
Krishna Anand Introduction. Lateral epicondylitis (LE) is caused by the overuse of the wrist extensors, typically from repetitive movements with the forearm in the pronated position1. Treatment options for patients with aggravating and persistent LE are limited non-operatively1. Current modalities of treatment include non-steroidal anti-inflammatory drugs, corticosteroid injections, and physical…
Engineering Medicine Inflammation Orthopedics

The Role of COX-2 And PGE2 in the Promotion of Neuroinflammation and Deposition of beta-Amyloid Protein in Alzheimer’s Disease

June 22, 2022 Chloe Todd
Chloe Todd Introduction: Alzheimer’s disease (AD) is the leading cause of dementia, projected to affect 150 million people worldwide by 2050.1 Current treatment focuses on improving patients’ symptoms; pharmacological therapy does not yet address disease pathology.2 AD pathogenesis begins with aggregation of β-amyloid (Aβ) protein in the brain.1 Amyloid precursor…
Featured Abstracts Inflammation Neuroscience

The Regulation of Macrophage Polarization through Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Osteoarthritis

June 22, 2022 Aniruth Srinivasaraghavan
Aniruth Srinivasaraghavan Introduction: Osteoarthritis (OA) is the irreversible degeneration and dysfunction of articular cartilage and adjacent tissues that eventually leads to joint destructions1,2. Non-pharmacological treatment such as exercise, weight loss, as walking aids as indicated are recommended for first line of treatment. Exercise therapy is recommended for helping to decrease…
Immunology Inflammation Orthopedics

Inhibition of AT1R-B2R Aggregates Decreases Endothelial Calcium Signaling and Alleviates Preeclampsia

June 12, 2022 Chantal Kinsey
Chantal Kinsey Introduction. Preeclampsia is the leading cause of death of pregnant women and the most common pregnancy complication with gestational hypertension leading to end-organ dysfunction.1,2 The mechanism by which preeclampsia induces organ damage is similar to other hypertensive conditions mediated by the upregulation of renin-angiotensin system (RAS) and downregulation…
Gynecology Inflammation Reproduction