Featured Featured Abstracts AI-Derived Digital Bone Age From Routine CT Imaging for Improved Fragility Fracture Risk PredictionEvaluating the Clinical Validation Criteria of Generative Models for De Novo Drug DiscoveryResting-State fMRI Changes in Motor Network Connectivity Before and After Resection of Low-Grade Gliomas Involving M1 or SMAComposite and Engineered Reconstruction Methods for Severe Burn WoundsProsthetic Valve Selection and Durability in Young Patients With Connective TissueEvaluating Genomic Methods for Assessing Fecal Microbiota Transplant (FMT) Efficacy After Antibiotic UseBioelectronic Systems for Advanced Wound Management: Integrating Monitoring, Direct Therapy, and Closed-Loop ControlResistance Training as a Therapeutic Intervention: Examining the Effects of Resistance Training on Common Chronic DiagnosesContact Lens Risk Behaviors and Treatment Response in Acanthamoeba KeratitisPrehospital Blood Product Transfusion in Traumatic Hypovolemic Shock: Advantages Over Crystalloid Resuscitation and Implications for Rural Trauma Carem6A RNA Modification in Cardiac Remodeling and Heart FailureThe Paradox of Pain Relief: Reevaluating the Opioid Standard in Acute Spinal Cord InjuryTargeting the NLRP3 Inflammasome for Neuroprotection in Traumatic Spinal Cord InjuryImpact of Surgical Approach on Early Outcomes of Total Hip ArthroplastyIntegrating Survival and Functional Prognostication in Glioblastoma TreatmentA Review of the Current Efforts to Regenerate Articular CartilageFrom weight loss to cardiovascular risk reduction: should GLP‑1/GIP obesity therapy change routine cardiometabolic care?Physeal-Sparing ACL Reconstruction With Concomitant Lateral Extra-Articular Tenodesis: Implications for Post-Traumatic Osteoarthritis RiskEmerging Roles of CRISPR Gene Editing in Cardiovascular Disease Research and TherapyThe Role of Demodex folliculorum Density in Modulating the Cutaneous Microbiome and Inflammatory Pathways in RosaceaBeyond Microfracture: AMIC for the Treatment of Focal Chondral DefectsA Cost-Benefit Analysis of the Production and Efficacy of Radionuclides in Targeted Prostate Cancer TherapyPressure-Sensitive Multivesicular Liposomes for Targeted Drug Delivery in High-Altitude Pulmonary EdemaOptimizing Bone Healing in Distal Femoral Osteotomy: The Role of Stiffness-Tunable Fixation PlatesConvection‑Enhanced Delivery in Glioblastoma: Insights from Early Human StudiesDual Versus Single Vascularized Lymph Node Transfer in Breast ReconstructionBeyond CTA: Imaging Guideline Considerations After Endovascular Aneurysm RepairEndothelial-to-Mesenchymal Transition as a Driver and Therapeutic Target in Cardiac Valvular FibrosisNeuromonitoring of Modifiable Risk Factors for Post-Operative DeliriumFailure-to-Rescue as a Mechanism of Socioeconomic Disparities in Oncologic SurgeryMechanisms of Osteolytic Bone Metastasis in Breast Cancer: RANKL Signaling, Bone Marrow Niche Programming, and RANKL-Independent Osteoclast ActivationAstrocyte Reactivity in Parkinson’s Disease and its Potential as a Target in Neuroprotective TherapyRadiation Induced Coronary Artery Disease From Endothelial Activation to Fibrotic Plaque: Molecular Mechanisms and Radiomic-Guided PreventionStructural Insights Driving Vaccine Innovation and Therapeutic Discovery for Oropouche Virus (OROV)Engineering Mesenchymal Stem Cell-Derived Exosomal miRNA Cargo to Restore Angiogenesis in Diabetic Foot UlcersNKCC1-Driven Excitatory GABAergic Signaling as a Subtype-Specific Growth Driver in H3K27M-Mutated Diffuse Midline GliomasPredicting the elusive connection between TREM2 and APOE in Alzheimer’s Disease: How Machine Learning can be a useful tool for uncovering hidden patterns in complex diseasesThe Role of Ubiquitination Regulation as a Mechanism of Trastuzumab Resistance in HER2-Positive Breast CancerStereotactic Body Radiotherapy to Enhance Immunotherapy Efficacy in Hepatocellular Carcinoma TreatmentGlucocorticoid Receptor as a Driver of Castration-Resistant Prostate CancerExercise To Combat Alzheimer’s DiseaseThe Role of Gut Microbiota-Derived Metabolites in the Pathogenesis and Clinical Translation of PreeclampsiaCD8+ T Cell-Mediated Hair Follicle Destruction and Failure of Tissue-Resident Regulatory T Cell Immune Privilege in Alopecia AreataTargeting the Truncated Splice Variant 7 of Androgen Receptor to Improve Treatment of Castration Resistant Prostate CancerTherapeutic Potential of Mycobacteriophages D29 and DS6A in Drug-Resistant Tuberculosis: A Preclinical Case for Phage-Based TherapyOvercoming T-cell Exhaustion in CAR-T cell TherapyCheckpoint Dysregulation and cGAS/STING Signaling as Initiators and Perpetuators of ANCA-Associated VasculitisFDX1 Downregulation and PI3K-AKT Pathway Activation in Hepatocellular CarcinomaSirolimus Therapy in Meigs’ Syndrome to Reduce Pleural EffusionNeutrophil Extracellular Trap (NET): its Effects on the Tumor Microenvironment and the Propagation of Lung CancerCalcium Mishandling via Ryanodine Receptor 2 Dysfunction May Contribute to Atrial FibrillationPaneth Cell Mitochondrial Dysfunction: An Epithelial Origin and Therapeutic Target of Ileal Crohn’s DiseaseCongenital Zika Risks and Clinical Presentation: Placental and Blood-Brain Barrier Crossing Through Disruption of Tight Junctions & TranscytosisRAAS Mediated TGF-β Signaling Drives Fibrosis and Lymphatic Dysfunction in Breast Cancer–Related Lymphedema: A Therapeutic TargetAdjunct Fentanyl Overdose Therapies: Expansion of Naloxone Efficacy with K-Opioid Receptor (KOR) and 2-adrenergic receptor agonistsThe Science of Socializing: NMDA Modulation in Autism-related Social DeficitsBiased Glucocorticoid Receptor Signaling in Duchenne Muscular Dystrophy: Moving Past the Monomer-Dimer DogmaBiomimetic Cascade-Driven Tissue Engineering for Critical-Size Bone Defect RepairPTEN Loss Drives Endometrial Carcinogenesis Through Coordinated Regulation of Proliferation, DNA Repair, and the Tumor Immune MicroenvironmentRadiation-induced Mesenchymal Stem Cell Dysfunction Links Mechanistic Injury to Emerging Regenerative TherapiesPathogenesis and Potential Targets of Non-Antibiotic Therapeutics Against Clostridioides difficile InfectionImaging Tumor Vasculature to Predict Metastatic Potential in Breast CancerA Novel Circular RNA-Mediated Regulatory Axis Driving the Malignant Transformation of Mesenchymal Stem Cells in OsteosarcomaCell Penetrating Peptide-Enabled Targeted Therapeutic Delivery in Triple Negative Breast Cancer ModelsCDCP1 Targeted Therapy in Triple Negative Breast CancerToll-Like Receptors in Human Papillomavirus Infections and Their Role in the Aggressiveness of Cervical CancerMiRNAs Play a Major Role in Mediating Tamoxifen Resistance in ERα+ Breast CancerMapping the Mechanistic Path from Ischemic Apoptosis to Clinical Heart Failure using Human-Derived Multi-Lineage Cardiac OrganoidsAutophagic Pathway as a Mediator of Intranasal Ketamine’s Effects in Treatment-Resistant Depression and Organ InjuryImproving Phosphorodiamidate Morpholino Oligomer (PMO) Therapy for Duchenne Muscular Dystrophy Via Cell-Penetrating Peptides (Cpps)Nitric Oxide Imbalances and Nitrosative Stress Drive Heart Failure with Preserved Ejection Fraction PathogenesisImpact of Anti-Fentanyl Vaccination on the Pharmacokinetics and Analgesic Efficacy of FentanylMSC-Derived Exosomes as a Cell-Free Therapy for IBS: Targeting Visceral Hypersensitivity via Neuroimmune and Oxidative Stress PathwaysStreptococcus gallolyticus subsp. gallolyticus Promotes Colorectal Tumorigenesis Through Disruption of Intestinal Epithelial HomeostasisInhibition of Traumatic Brain Injury Derived Tauopathies Using Aβ1-6A2V(D) Peptide TherapyMitochondrial ferroptosis in Doxorubicin-induced CardiotoxicityRIP3-Mediated Microglial Necroptosis Drives Neuroinflammation and Retinal Neurodegeneration in Diabetic RetinopathyMedulloblastoma Treatments are Seeking Novel Mechanisms to Improve Targeted Drug DeliveryIncreased β-Catenin Signaling in Obesity-Associated Triple-Negative Breast Cancer ProgressionThe Role of Macrophages in the Pathogenesis of Connective Tissue Disease Associated Interstitial Lung DiseaseThe Impact of Obesity on the Tumor Microenvironment of Breast CancerMaternal Choline as a Methyl Donor: One-Carbon Metabolism, DNA Methylation, and Risk of Neural Tube DefectsHMGB1-Rage Signaling as a Driver of Lymphatic Remodeling in Post-Traumatic Acute Kidney InjuryMechanistic Basis and Translational Development of HER2 Antibody Drug Conjugates for HER2-Positive Breast Cancer Brain MetastasesThe Exploration of Viral IE2 Regulatory Protein on the TSC2-mTOR Pathway as a Mechanism for Congenital Cytomegalovirus Induced Sensorineural Hearing LossDark Microglia and the Integrated Stress Response: A Stress-Metabolic Mechanism of Neurodegeneration in Alzheimer’s DiseaseThe Mechanism of Ferrostatin-1 Inhibition of Ferroptosis in Multiple SclerosisTP53 Dysfunction Alters the DNA Damage Response and Influences RadiosensitivityTGF-β – Mediated Tumor Microenvironment Alterations Linking Hodgkin’s Lymphoma to Secondary Breast CancerGut IgA Dysregulation and B-Cell Dysfunction in Multiple Sclerosis4MiR-27a as a Molecular Mediator of Tumor Microenvironment–Driven Therapy Resistance in Stage IV Rectal AdenocarcinomaTargeting FGFR2 in Intrahepatic Cholangiocarcinoma: From Bench Models to Resistance Mechanisms and Future Targeted Treatment StrategiesHormone-Regulated Macrophage Infiltration and Cytokine Signaling in Endometrial Intraepithelial Neoplasia and Progestin ResistanceBiomarkers of chronic inflammation to monitor disease progression and cancer riskThe Role of sFlt-1–Mediated VEGFA Suppression in Trophoblast Dysfunction and Placental InsufficiencyAspirin and NSAID-Mediated Epigenetic Modulation in Colorectal Cancer PreventionAnti-CD19 CAR T Cell Therapy in Systemic Lupus ErythematosusThe Multifaceted Role of Cancer-associated Fibroblasts in the Progression and Metastases of OsteosarcomaTreatments for Neuropathology Induced by Branched-Chain Amino Acids in Maple Syrup Urine DiseasePostsurgical Lymphatic Regeneration: Potential of 9-cis-RA and VEGF-C Combined TherapyLow-Dose Interleukin-2 Therapy in Systemic Lupus Erythematosus: Restoring Immune Tolerance Through Targeted Regulatory T-Cell ExpansionEphA4 in Alzheimer’s Disease: A Pathogenic Driver and Promising Therapeutic TargetDevelopment of Human Cytomegalovirus Glycoprotein B and Pentamer Complex Subunit Vaccines to Elicit Protective Immune Response Against Congenital Cytomegalovirus InfectionsTherapeutic Advancements for the Treatment of Melanoma: Striving for an Individualized Approach by Targeting MAPK and Hippo PathwaysYoga as a Supplemental Therapy for Pediatric Cystic Fibrosis PatientsThe Role of Vitamin K2-MK4 in Parkinson’s DiseaseEngineering CAR-T Cells to Enhance Anti-tumorigenic Properties for Cancer TreatmentAdvancements in Alzheimer’s Disease Detection and TreatmentThe Role of Selective Dopamine D2 Agonists in Promoting Cardiomyocyte Recovery in Oxidative Stress-induced Peripartum CardiomyopathyRevolutionizing Parkinson’s Disease Treatment: Focused Ultrasound for Non-Invasive Gene Delivery Across the Blood-Brain BarrierWhat Can Be Done to Structurally or Biologically Support the Apophysis of the Tibia in Children Who Suffer from Osgood-Schlatter Disease So That They May Continue Activity During Their Childhood?A Review of the Limitations and Future Directions of Kyphoplasty for Symptomatic Vertebral Compression FracturesFood for Thought: Exploring Dietary Influence on the Gut-Brain Axis and its Implications for Neuropsychiatric DisordersInvestigating the Viral, Genomic, and Immunological Etiology of Type 1 Diabetes MellitusComputational Methods for Early Detection of Diabetic RetinopathyS100A1 as a Therapeutic Peptide Target for Heart FailureALDH2 Deficiency in Alcohol-Associated Hepatocellular Carcinoma: Mechanisms and Potential Drug TherapyPatient-Specific 3D-Printed Guides in Total Knee Arthroplasty: Implications for Soft Tissue Balancing and ProprioceptionSex Differences in Traumatic Brain Injury Outcomes in Survivors of Intimate Partner ViolenceBiomarkers and Clinical Indicators of Long-COVID Associated Brain FogImmunotherapy Approaches in NeuroblastomaMesenchymal Stem Cells (MSCs) and MSC-Derivatives for Improving Outcomes with Sepsis-Induced Acute Respiratory Distress SyndromeChallenges and Opportunities in the Treatment of Patients with Waldenström MacroglobulinemiaImproving smile synchronicity of smile development in patients undergoing facial nerve reanimationThe Lack of Comorbidity Between Early Cortical Blindness and SchizophreniaRewiring Pain: Brain-Computer Interface and Mixed Virtual Reality Approaches to Addressing Phantom Limb PainSoft Robotic Cardiac Support Devices: The Next Generation of Heart Failure TreatmentInclusion Body Myositis and Exercise – Will It Help or Hurt?Artificial Intelligence in Glioblastoma Radiotherapy: Precision Mapping to Reduce ToxicityA Comparative Analysis of Trans-hiatal and Transthoracic Surgical Approaches for EsophagectomyThe Role of the Gut-Brain Axis in Major Depressive DisorderThe Role of Adiponectin in Glycemic Effects of Intermittent Fasting on Type 2 Diabetes MellitusInvestigation of Novel Pharmacologic Regimens for the Treatment and Prevention of Retinopathy of PrematurityAssessing the Effects of Space Travel on the Gut Microbiome and the Potential Impacts on Future Mission PlanningTracheal Reconstruction: State of the ArtNeonatal Respiratory Distress Syndrome Management in Resource-Limited SettingsPostoperative Peripheral Neuropathy (PPN): A Comprehensive Literature Review of Incidence Rates and Contributory VariablesOpportunities for Automating Clinical Decision-Making Tasks in Primary CareAddressing the Prognostic Challenges of Pancreatic Ductal AdenocarcinomaEfficacy of Platelet-Rich Plasma (PRP) Injections in the Treatment of BursitisEvaluating the Efficacy of Gene Therapy in Treating Inherited Retinal DiseasesHepatocellular Carcinoma in the Context of Regenerative Liver Hyperplasia: Mechanisms of Metaplasticity Prevention in the Paradigm Adaptive OrganEffects of a Vegan Diet on Heart Disease and DiabetesThe Activation of Molecular and Cellular Pathways in the Hippocampus Following Traumatic Brain InjuryInnovations in Heart Transplantation: The Role of Gene Therapy and Tissue EngineeringRole of Surgical Technique in Outcomes after Meniscal RepairMolecules in Motion: Exercise-Induced Adiponectin Inhibits Angiogenesis in Diabetic RetinopathyP2Y₂ Receptor Signaling as a Therapeutic Target in Coronary Microvascular DysfunctionChronic Oxytocin Administration as a Potential Epigenetic Therapeutic for Autism Spectrum DisorderUse of Low-cost Congenital Heart Defect Models to Train Surgeons in Low-Resource Settings
